发明申请
US20090143615A1 Process for the Preparation of (S)(+)-3-(Aminomethyl)-5-Methylhexanoic Acid
审中-公开
（S）（+） - 3-（氨基甲基）-5-甲基己酸的制备方法
- 专利标题： Process for the Preparation of (S)(+)-3-(Aminomethyl)-5-Methylhexanoic Acid
- 专利标题（中）： （S）（+） - 3-（氨基甲基）-5-甲基己酸的制备方法
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申请号： US12327191申请日： 2008-12-03
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公开(公告)号： US20090143615A1公开(公告)日： 2009-06-04
- 发明人: Pietro Allegrini , Simone Mantegazza , Dario Pastorello , Gabriele Razzetti
- 申请人： Pietro Allegrini , Simone Mantegazza , Dario Pastorello , Gabriele Razzetti
- 申请人地址： IT Baranzate (MI)
- 专利权人： Dipharma Francis S.r.l.
- 当前专利权人： Dipharma Francis S.r.l.
- 当前专利权人地址： IT Baranzate (MI)
- 优先权： ITMI2007A002262 20071203
- 主分类号： C07C229/04
- IPC分类号： C07C229/04 ; C07C243/10
摘要：
A process for the preparation of a compound of formula (I), comprising:a) the reaction of a compound of formula (II) with hydrazine to obtain a compound of formula (III), b) the conversion of a compound of formula (III) by rearrangement via formation of nitrene/isocyanate, in a solvent of formula R1—OH, wherein R1 is as herein defined, to obtain a compound of formula (IV); c) the enantiomeric enrichment of a compound of formula (IV) to obtain the enantiomer (S) of a compound of formula (V) d) the hydrolysis of a compound of formula (V).
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