发明申请
US20090149428A1 Methods for Assessing the Predisposition or Susceptibility to COPD
审中-公开
评估COPD倾向或易感性的方法
- 专利标题： Methods for Assessing the Predisposition or Susceptibility to COPD
- 专利标题（中）： 评估COPD倾向或易感性的方法
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申请号： US11719607申请日： 2005-11-16
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公开(公告)号： US20090149428A1公开(公告)日： 2009-06-11
- 发明人: Simon Smith
- 申请人： Simon Smith
- 申请人地址： SE Sodertalje
- 专利权人： AstraZeneca AB
- 当前专利权人： AstraZeneca AB
- 当前专利权人地址： SE Sodertalje
- 优先权： SE0402832-0 20041118
- 国际申请： PCT/SE05/01726 WO 20051116
- 主分类号： A61K31/522
- IPC分类号： A61K31/522 ; C12Q1/68 ; A61K31/197 ; A61P11/00 ; A61K31/56 ; C07H21/00
摘要：
This invention relates to novel associations between polymorphisms in the genes encoding the human Epithelial Na+ Channel (ENaC) and COPD. More particularly, the invention relates to a method for assessing the predisposition and/or susceptibility of an individual to COPD, which method comprises detecting the presence of a polymorphism in one or more human ENaC-encoding genes, in particular position 3870 of SEQ ID:1 encoding SCNN1B or position 10544 of SEQ ID NO: 2 encoding SCNN1G. The invention also relates to a method of treating a human identified as having a polymorphism in one or more human ENaC-encoding genes with a drug capable of treating COPD.
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