发明申请
- 专利标题: DUAL-ACTING BENZOIMIDAZOLE ANTIHYPERTENSIVE AGENTS
- 专利标题(中): 双作用苯唑咪唑抗生素
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申请号: US12330289申请日: 2008-12-08
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公开(公告)号: US20090149521A1公开(公告)日: 2009-06-11
- 发明人: Seok-Ki Choi , Paul R. Fatheree , Robert Murray McKinnell , Brooke Olson
- 申请人: Seok-Ki Choi , Paul R. Fatheree , Robert Murray McKinnell , Brooke Olson
- 主分类号: A61K31/4184
- IPC分类号: A61K31/4184 ; C07D235/16 ; C07D403/08
摘要:
The invention relates to compounds having the formula: wherein Ar, r, n, X, R2, R2′, R3, and R5-7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and a process and intermediates for preparing such compounds.
公开/授权文献
- US08212052B2 Dual-acting benzoimidazole antihypertensive agents 公开/授权日:2012-07-03
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