- 专利标题： ANTIBODIES DIRECTED TO THE DELETION MUTANTS OF EPIDERMAL GROWTH FACTOR RECEPTOR AND USES THEREOF
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申请号： US12268352申请日： 2008-11-10
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公开(公告)号： US20090155282A1公开(公告)日： 2009-06-18
- 发明人: Richard Weber , Xiao Feng , Orit Foord , Larry Green , Jean M. Gudas , Bruce Keyt , Ying Liu , Palaniswami Rathanaswami , Robert Raya , Xiao Dong Yang , Jose Corvalan , Ian Foltz , Xiao-Chi Jia , Jaspal S. Kang , Chadwick T. King , Scott L. Klakamp , Qiaojuan Jane Su
- 申请人： Richard Weber , Xiao Feng , Orit Foord , Larry Green , Jean M. Gudas , Bruce Keyt , Ying Liu , Palaniswami Rathanaswami , Robert Raya , Xiao Dong Yang , Jose Corvalan , Ian Foltz , Xiao-Chi Jia , Jaspal S. Kang , Chadwick T. King , Scott L. Klakamp , Qiaojuan Jane Su
- 申请人地址： US CA Fremont
- 专利权人： Amgen Fremont Inc.
- 当前专利权人： Amgen Fremont Inc.
- 当前专利权人地址： US CA Fremont
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C12N5/02 ; C07H21/04
摘要：
The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.
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