发明申请
US20090156591A1 Thiophene and Thiazole Substituted trifluoroethanone Derivatives as Histone Deacetylase (Hdac) Inhibitors
有权
噻吩和噻唑取代的三氟乙酮衍生物作为组蛋白脱乙酰酶（Hdac）抑制剂
- 专利标题： Thiophene and Thiazole Substituted trifluoroethanone Derivatives as Histone Deacetylase (Hdac) Inhibitors
- 专利标题（中）： 噻吩和噻唑取代的三氟乙酮衍生物作为组蛋白脱乙酰酶（Hdac）抑制剂
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申请号： US11991576申请日： 2006-09-05
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公开(公告)号： US20090156591A1公开(公告)日： 2009-06-18
- 发明人: Federica Ferrigno , Philip Jones , Ester Muraglia , Jesus Maria Ontoria Ontoria , Rita Scarpelli
- 申请人： Federica Ferrigno , Philip Jones , Ester Muraglia , Jesus Maria Ontoria Ontoria , Rita Scarpelli
- 优先权： GB0518237.3 20050907
- 国际申请： PCT/GB2006/050274 WO 20060905
- 主分类号： A61K31/47
- IPC分类号： A61K31/47 ; C07D409/02 ; C07D417/02 ; C07D265/30 ; A61K31/496 ; A61K31/5375 ; A61P25/18 ; A61P25/28
摘要：
The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt or stereoisomer thereof. The compounds of the present invention are inhibitors of histone deacetylase (HDAC) and are useful for treating cellular proliferative diseases, including cancer. Further, the compounds of the present invention are useful for treating neurodegenerative diseases, schizophrenia and stroke among other diseases.
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