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    METHODS
    1.
    发明公开
    METHODS 审中-公开

    公开(公告)号：US20240360077A1

    公开(公告)日：2024-10-31

    申请号：US18537093

    申请日：2023-12-12

    申请人： Aeromics, Inc.

    发明人： Marc F. Pelletier ,  George William Farr ,  Paul Robert McGuirk ,  Christopher H. Hall ,  Walter F. Boron

    IPC分类号： C07C235/64 ,  A61K31/167 ,  A61K31/24 ,  A61K31/5375 ,  A61K31/661 ,  A61K31/6615 ,  C07D295/185 ,  C07F9/12

    CPC分类号： C07C235/64 ,  A61K31/167 ,  A61K31/24 ,  A61K31/5375 ,  A61K31/661 ,  A61K31/6615 ,  C07D295/185 ,  C07F9/12

    摘要： The present invention relates to the use of selective aquaporin inhibitors, e.g., of aquaporin-4 or aquaporin-2, e.g., certain phenylbenzamide compounds, for the prophylaxis, treatment and control of aquaporin-mediated conditions, e.g., diseases ofwater imbalance, for example edema (particularly edema of the brain and spinal cord, e.g., following trauma or ischemic stroke, as well as the edema associated with glioma, meningitis, acute mountain sickness, epileptic seizures, infections, metabolic disorders, hypoxia, water intoxication, hepatic failure, hepatic encephalopathy, diabetic ketoacidosis, abscess, eclampsia, Creutzfeldt-Jakob disease, and lupus cerebritis, as well as edema consequent to microgravity and/or radiation exposure, as well as edema consequent to invasive central nervous system procedures, e.g., neurosurgery, endovascular clot removal, spinal tap, aneurysm repair, or deep brain stimulation, as well as retinal edema), as well as hyponatremia and excess fluid retention, and diseases such as epilepsy, retinal ischemia and other diseases of the eye associated with abnormalities in intraocular pressure and/or tissue hydration, myocardial ischemia, myocardial ischemia/reperfusion injury, myocardial infarction, myocardial hypoxia, congestive heart failure, sepsis, and neuromyelitis optica, as well as migraines, as well as to novel assays for identifying aquaporin inhibitors.