发明申请
- 专利标题： HETEROARYL DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS
- 专利标题（中）： 异丙肾上腺素衍生物作为OREXIN受体拮抗剂
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申请号： US12334559申请日： 2008-12-15
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公开(公告)号： US20090163485A1公开(公告)日： 2009-06-25
- 发明人: Henner Knust , Matthias Nettekoven , Emmanuel Pinard , Olivier Roche , Mark Rogers-Evans
- 申请人： Henner Knust , Matthias Nettekoven , Emmanuel Pinard , Olivier Roche , Mark Rogers-Evans
- 优先权： EP07150294.2 20071221
- 主分类号： A61K31/5365
- IPC分类号： A61K31/5365 ; C07D263/54 ; A61K31/421 ; C07D241/36 ; A61K31/498 ; C07D417/02 ; A61K31/428 ; C07D221/00 ; A61K31/4245 ; A61P25/00 ; A61K31/501 ; C07D403/02 ; A61K31/505 ; C07D239/24 ; C07D271/06 ; A61K31/454 ; C07D215/38 ; A61K31/4709 ; C07D239/72 ; A61K31/517 ; C07D265/12
摘要：
The present invention relates to compounds of formula wherein Ar, Het, R1 and n are as defined herein and to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. Compounds of formula I are orexin receptor antagonists and are useful in the treatment of sleep apnea, narcolepsy, insomnia, parasomnia, jet lag syndrome, circadian rhythms disorder and sleep disorders associated with neurological diseases.
公开/授权文献
- US07897627B2 Heteroaryl derivatives as orexin receptor antagonists 公开/授权日：2011-03-01
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