发明申请
US20090163487A1 N-HYDROXYLSULFONAMIDE DERIVATIVES AS NEW PHYSIOLOGICALLY USEFUL NITROXYL DONORS
有权
N-羟基磺酰胺衍生物作为新生物学上有用的硝基衍生物
- 专利标题： N-HYDROXYLSULFONAMIDE DERIVATIVES AS NEW PHYSIOLOGICALLY USEFUL NITROXYL DONORS
- 专利标题（中）： N-羟基磺酰胺衍生物作为新生物学上有用的硝基衍生物
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申请号： US12239705申请日： 2008-09-26
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公开(公告)号： US20090163487A1公开(公告)日： 2009-06-25
- 发明人: John P. Toscano , Frederick Arthur Brookfield , Andrew D. Cohen , Stephen Martin Courtney , Lisa Marie Frost , Vincent Jacob Kalish
- 申请人： John P. Toscano , Frederick Arthur Brookfield , Andrew D. Cohen , Stephen Martin Courtney , Lisa Marie Frost , Vincent Jacob Kalish
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; C07C311/16 ; A61K31/24 ; A61K31/195 ; A61K31/18 ; C07D265/30 ; A61K31/5375 ; C07D413/12 ; A61P9/04
摘要：
The invention relates to N-hydroxylsulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxylsulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxylsulfonamide derivatives.