发明申请
- 专利标题: Pharmaceutical Composition Comprising an Amide Derivative
- 专利标题(中): 包含酰胺衍生物的药物组合物
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申请号: US12085941申请日: 2006-12-13
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公开(公告)号: US20090163549A1公开(公告)日: 2009-06-25
- 发明人: Hiroyuki Kai
- 申请人: Hiroyuki Kai
- 优先权: JP2005-361643 20051215
- 国际申请: PCT/JP2006/325313 WO 20061213
- 主分类号: A61K31/167
- IPC分类号: A61K31/167 ; A61K31/4433 ; A61K31/4439 ; A61K31/4245 ; A61K31/426 ; A61K31/421 ; A61K31/42 ; A61K31/357 ; C07D405/12 ; C07D271/07 ; C07D277/10 ; C07D263/06 ; C07D261/04 ; C07D233/02 ; C07D319/06 ; C07C237/28 ; C07C235/84
摘要:
The present invention provides a novel modulator of the TRPV1-receptor function, comprising a compound of the formula; wherein ring A is an optionally substituted carbocycle or heterocycle, ring B is an optionally substituted benzene ring or an optionally substituted 6-membered heteroaromatic ring containing N atom, a dashed line means existence or absence of a bond, n is 1 or 2, R1 and R2 are hydrogen etc., R3 is lower alkyl, R4 is lower alkyl or aryloxy, or R3 and R4 taken together may form optionally substituted 5- or 6-membered non-aromatic heterocycle.
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