发明申请
- 专利标题： Stimulus Inducible Protein Kinase Complex and Methods of Use Therefor
- 专利标题（中）： 刺激诱导蛋白激酶复合物及其使用方法
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申请号： US11876570申请日： 2007-10-22
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公开(公告)号： US20090169564A1公开(公告)日： 2009-07-02
- 发明人: Frank Mercurio , Hengyi Zhu , Miguel Barbosa , Jian Wu Li , Brion W. Murray
- 申请人： Frank Mercurio , Hengyi Zhu , Miguel Barbosa , Jian Wu Li , Brion W. Murray
- 专利权人： Signal Pharmaceuticals, Inc.
- 当前专利权人： Signal Pharmaceuticals, Inc.
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/18 ; A61K31/7088 ; G01N33/573
摘要：
Compositions and methods are provided for treating NF-κB-related conditions. In particular, the invention provides a stimulus-inducible IKK signalsome, and components and variants thereof. An IKK signalsome or component thereof may be used, for example, to identify antibodies and other modulating agents that inhibit or activate signal transduction via the NF-κB cascade. IKK signalsome, components thereof and/or modulating agents may also be used for the treatment of diseases associated with NF-κB activation.
公开/授权文献
- US07759476B2 Double-stranded RNAS directed to IKK-2 公开/授权日：2010-07-20
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