发明申请
US20090176803A1 CINNAMOYL-PIPERAZINE DERIVATIVES AND THEIR USE AS PAR-1 ANTAGONISTS
有权
CINNAMOYL-PIPERAZINE衍生物及其作为PAR-1拮抗剂的用途
- 专利标题： CINNAMOYL-PIPERAZINE DERIVATIVES AND THEIR USE AS PAR-1 ANTAGONISTS
- 专利标题（中）： CINNAMOYL-PIPERAZINE衍生物及其作为PAR-1拮抗剂的用途
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申请号： US12305584申请日： 2007-06-19
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公开(公告)号： US20090176803A1公开(公告)日： 2009-07-09
- 发明人: Michel Perez , Marie Lamothe , Bruno Le Grand , Robert Letienne
- 申请人： Michel Perez , Marie Lamothe , Bruno Le Grand , Robert Letienne
- 优先权： FR0605419 20060619
- 国际申请： PCT/EP07/56086 WO 20070619
- 主分类号： A61K31/4965
- IPC分类号： A61K31/4965 ; C07D241/04 ; A61P3/00 ; A61P1/00 ; A61P7/00 ; A61P21/00
摘要：
The present invention relates to compounds of general formula (I): wherein: R1 represents: halogen, CN or NO2; R2 represents: hydrogen or halogen; n represents: 1 or 2; R3 represents: phenyl substituted by one or more halogens or C1-C6 alkyls; or a cyclohexyl; as well as the therapeutically-acceptable salts or solvates thereof. These compounds are useful as protease-activated receptor-1 (PAR-1) antagonists, particularly in the treatment of thrombosis.
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