-
公开(公告)号：US08486085B2
公开(公告)日：2013-07-16
申请号：US13040727
申请日：2011-03-04
申请人： Gerhard Moeller , Anja Seiwert , Michel Perez , Peter Amend
发明人： Gerhard Moeller , Anja Seiwert , Michel Perez , Peter Amend
IPC分类号： A61F9/00
摘要： A surgical microscopy system comprises microscopy optics for generating an image of an eye under surgery. A pattern generator generates a pattern to be superimposed with the image. An eye-tracker is provided for tracking a position of the superimposed pattern with respect to the image in case of a movement of the eye. The superimposed pattern comprises pattern elements that are equally distributed on first and second circles of different sizes, in order to give assistance when placing a suture during a corneal transplant. The superimposed pattern may also provide an assistance for orientating a toric intra-ocular lens.
摘要翻译： 手术显微镜系统包括用于在手术下产生眼睛图像的显微镜光学器件。 图案生成器生成与图像叠加的图案。 提供了一种眼睛跟踪器，用于在眼睛移动的情况下跟踪相对于图像的叠加图案的位置。 叠加图案包括均匀分布在不同大小的第一和第二圆上的图案元件，以便在角膜移植期间放置缝合线时给予帮助。 叠加图案还可以提供用于定向复曲面眼内透镜的辅助。
-
2.发明申请CINNAMOYL-PIPERAZINE DERIVATIVES AND THEIR USE AS PAR-1 ANTAGONISTS 有权CINNAMOYL-PIPERAZINE衍生物及其作为PAR-1拮抗剂的用途公开(公告)号：US20120232097A1
公开(公告)日：2012-09-13
申请号：US13476487
申请日：2012-05-21
申请人： Michel PEREZ , Marie Lamothe , Bruno Le Grand , Robert Letienne
发明人： Michel PEREZ , Marie Lamothe , Bruno Le Grand , Robert Letienne
IPC分类号： A61K31/495 , A61P7/02 , A61P9/00 , A61P9/06 , A61P9/04 , A61P9/12 , A61P9/10 , A61P29/00 , A61P11/00 , A61P1/00 , A61P1/16 , A61P17/00 , A61P35/00 , A61P43/00 , C07D295/192
CPC分类号： C07D295/185
摘要： The present invention relates to compounds of general formula (I): wherein: R1 represents: halogen, CN or NO2; R2 represents: hydrogen or halogen; n represents: 1 or 2; R3 represents: phenyl substituted by one or more halogens or C1-C6 alkyls; or a cyclohexyl; as well as the therapeutically-acceptable salts or solvates thereof. These compounds are useful as protease-activated receptor-1 (PAR-1) antagonists, particularly in the treatment of thrombosis.
摘要翻译： 本发明涉及通式（I）的化合物：其中：R1表示：卤素，CN或NO2; R2表示：氢或卤素; n表示1或2; R3表示：被一个或多个卤素或C 1 -C 6烷基取代的苯基; 或环己基; 以及其治疗上可接受的盐或溶剂合物。 这些化合物可用作蛋白酶激活受体-1（PAR-1）拮抗剂，特别是治疗血栓形成。
-
3.发明申请CINNAMOYL-PIPERAZINE DERIVATIVES AND THEIR USE AS PAR-1 ANTAGONISTS 有权CINNAMOYL-PIPERAZINE衍生物及其作为PAR-1拮抗剂的用途公开(公告)号：US20090176803A1
公开(公告)日：2009-07-09
申请号：US12305584
申请日：2007-06-19
申请人： Michel Perez , Marie Lamothe , Bruno Le Grand , Robert Letienne
发明人： Michel Perez , Marie Lamothe , Bruno Le Grand , Robert Letienne
IPC分类号： A61K31/4965 , C07D241/04 , A61P3/00 , A61P1/00 , A61P7/00 , A61P21/00
CPC分类号： C07D295/185
摘要： The present invention relates to compounds of general formula (I): wherein: R1 represents: halogen, CN or NO2; R2 represents: hydrogen or halogen; n represents: 1 or 2; R3 represents: phenyl substituted by one or more halogens or C1-C6 alkyls; or a cyclohexyl; as well as the therapeutically-acceptable salts or solvates thereof. These compounds are useful as protease-activated receptor-1 (PAR-1) antagonists, particularly in the treatment of thrombosis.
摘要翻译： 本发明涉及通式（I）的化合物：其中：R1表示：卤素，CN或NO2; R2表示：氢或卤素; n表示1或2; R3表示：被一个或多个卤素或C 1 -C 6烷基取代的苯基; 或环己基; 以及其治疗上可接受的盐或溶剂合物。 这些化合物可用作蛋白酶激活受体-1（PAR-1）拮抗剂，特别是治疗血栓形成。
-
公开(公告)号：US20060247659A1
公开(公告)日：2006-11-02
申请号：US11259556
申请日：2005-10-26
申请人： Gerhard Moeller , Anja Seiwert , Michel Perez , Peter Amend
发明人： Gerhard Moeller , Anja Seiwert , Michel Perez , Peter Amend
摘要： A surgical microscopy system comprises microscopy optics for generating an image of an eye under surgery. A pattern generator generates a pattern to be superimposed with the image. An eye-tracker is provided for tracking a position of the superimposed pattern with respect to the image in case of a movement of the eye. The superimposed pattern comprises pattern elements that are equally distributed on first and second circles of different sizes, in order to give assistance when placing a suture during a corneal transplant. The superimposed pattern may also provide an assistance for orientating a toric intra-ocular lens.
-
5.发明授权Methanesulphonate salt of an arylpiperazine derived from tryptamine and its solvates for pharmaceutical use 失效衍生自色胺的芳基哌嗪的甲磺酸盐及其药物用溶剂化物
公开(公告)号：US6110917A
公开(公告)日：2000-08-29
申请号：US202539
申请日：1998-12-16
申请人： Serge Halazy , Michel Perez
发明人： Serge Halazy , Michel Perez
IPC分类号： A61K31/00 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/4045 , A61P25/04 , A61P43/00 , C07D209/16 , A01N43/60 , A61K31/495
CPC分类号： C07D209/16
摘要： The invention discloses the methanesulphonate salt of 4-(4-{2-[3-(2-amino-ethyl)-1H-indol-5-yloxy]-acetyl}-piperazin-1-yl)-benzonitrile, its solvates or hydrates as well as the preparation of the said salt. The invention also discloses the pharmaceutical compositions containing the said salt, useful in the preparation of medicines for treating vasospastic disorders.
摘要翻译： PCT No.PCT / FR97 / 01053 Sec。 371日期1998年12月16日第 102（e）日期1998年12月16日PCT提交1997年6月12日PCT公布。 公开号WO97 / 48680 PCT 日期1997年12月24日本发明公开了4-（4- {2- [3-（2-氨基 - 乙基）-1H-吲哚-5-基氧基] - 乙酰基} - 哌嗪-1-基） - 苄腈，其溶剂合物或水合物以及所述盐的制备。 本发明还公开了含有所述盐的药物组合物，其可用于制备治疗血管痉挛性疾病的药物。
-
6.发明授权公开(公告)号：US08022064B2
公开(公告)日：2011-09-20
申请号：US12305447
申请日：2007-06-19
申请人： Michel Perez , Marie Lamothe , Bruno Le Grand , Robert Letienne
发明人： Michel Perez , Marie Lamothe , Bruno Le Grand , Robert Letienne
IPC分类号： A61K31/496 , A61K31/495 , A61K31/551 , C07D213/74 , C07D213/75 , C07D333/24 , C07D295/1851
CPC分类号： C07D295/192 , C07D213/74 , C07D295/112
摘要： The present invention relates to compounds of general formula (I): wherein: R1 and R2, identical or different, represent: an atom of hydrogen or halogen, CN or NO2, with R1 and R2 not representing hydrogen simultaneously, m represents: 1 or 2 n represents: 0, 1 or 2 R3 represents: phenyl substituted or not by one or more residues chosen among halogen, hydroxyl or C1-C6 alkyl; C2-C6 alkyl substituted or not by one or more residues chosen among halogen or hydroxyl; cycloalkyl; pyridine; thiophene; pyrrole substituted or not by C1-C6 alkyl; thiazole or furan; or the therapeutically-acceptable salts or solvates thereof.
摘要翻译： 本发明涉及通式（I）的化合物：其中：R1和R2相同或不同，代表氢原子或卤素，CN或NO2，其中R1和R2不同时代表氢，m表示：1或 2 n表示：0,1或2 R 3表示：被一个或多个选自卤素，羟基或C 1 -C 6烷基的残基取代或不被取代的苯基; 被一个或多个选自卤素或羟基的残基取代或不被其取代的C 2 -C 6烷基; 环烷基 吡啶; 噻吩 被C1-C6烷基取代或未取代的吡咯; 噻唑或呋喃; 或其治疗上可接受的盐或溶剂化物。
-
公开(公告)号：US09462944B2
公开(公告)日：2016-10-11
申请号：US13040699
申请日：2011-03-04
申请人： Gerhard Moeller , Anja Seiwert , Michel Perez , Peter Amend
发明人： Gerhard Moeller , Anja Seiwert , Michel Perez , Peter Amend
摘要： A surgical microscopy system comprises microscopy optics for generating an image of an eye under surgery. A pattern generator generates a pattern to be superimposed with the image. An eye-tracker is provided for tracking a position of the superimposed pattern with respect to the image in case of a movement of the eye. The superimposed pattern comprises pattern elements that are equally distributed on first and second circles of different sizes, in order to give assistance when placing a suture during a corneal transplant. The superimposed pattern may also provide an assistance for orientating a toric intra-ocular lens.
-
公开(公告)号：US20110153013A1
公开(公告)日：2011-06-23
申请号：US13040699
申请日：2011-03-04
申请人： Gerhard MOELLER , Anja SEIWERT , Michel PEREZ , Peter AMEND
发明人： Gerhard MOELLER , Anja SEIWERT , Michel PEREZ , Peter AMEND
IPC分类号： A61F2/14
摘要： A surgical microscopy system comprises microscopy optics for generating an image of an eye under surgery. A pattern generator generates a pattern to be superimposed with the image. An eye-tracker is provided for tracking a position of the superimposed pattern with respect to the image in case of a movement of the eye. The superimposed pattern comprises pattern elements that are equally distributed on first and second circles of different sizes, in order to give assistance when placing a suture during a corneal transplant. The superimposed pattern may also provide an assistance for orientating a toric intra-ocular lens.
-
9.发明授权Derivatives of benzothiazines, preparation thereof and application thereof as drugs 有权苯并噻嗪类的衍生物，其制备方法及作为药物的应用公开(公告)号：US09187438B2
公开(公告)日：2015-11-17
申请号：US13254473
申请日：2010-03-02
申请人： Michel Perez , Marie Lamothe , Didier Junquero , Yves Rival
发明人： Michel Perez , Marie Lamothe , Didier Junquero , Yves Rival
IPC分类号： A61K38/28 , A61P5/50 , A61K38/26 , A61P3/10 , A61P7/12 , C07K14/605 , A61K31/54 , C07D279/16 , C07D275/06
CPC分类号： C07D275/06
摘要： The object of the present invention is benzothiazine derivatives having the capability of inhibiting 11β-HSD1 not only at an enzymatic level but also at a cell level. The compounds of the present invention are of general formula (I). Wherein notably R1 represents a hydrogen or OR1 represents an ester or an ether. R2 represents a naphthyl or a 1,2,3,4-tetrahydro-naphthalene or a biphenyl or phenyl pyridine or a substituted phenyl. R3 represents a methyl or ethyl; R4 and R′4 represent a hydrogen.
摘要翻译： 本发明的目的是不仅在酶水平而且在细胞水平上具有抑制11＆lt; bgr--HSD1能力的苯并噻嗪衍生物。 本发明的化合物具有通式（I）。 其中R1表示氢或OR1表示酯或醚。 R 2表示萘基或1,2,3,4-四氢 - 萘或联苯基或苯基吡啶或取代的苯基。 R3表示甲基或乙基; R 4和R 4代表氢。
-
10.发明授权公开(公告)号：US08513258B2
公开(公告)日：2013-08-20
申请号：US13476487
申请日：2012-05-21
申请人： Michel Perez , Marie Lamothe , Bruno Le Grand , Robert Letienne
发明人： Michel Perez , Marie Lamothe , Bruno Le Grand , Robert Letienne
IPC分类号： A61K31/495 , C07D295/185
CPC分类号： C07D295/185
摘要： The present invention relates to compounds of general formula (I): wherein: R1 represents: halogen, CN or NO2; R2 represents: hydrogen or halogen; n represents: 1 or 2; R3 represents: phenyl substituted by one or more halogens or C1-C6 alkyls; or a cyclohexyl; as well as the therapeutically-acceptable salts or solvates thereof. These compounds are useful as protease-activated receptor-1 (PAR-1) antagonists, particularly in the treatment of thrombosis.
摘要翻译： 本发明涉及通式（I）的化合物：其中：R1表示：卤素，CN或NO2; R2表示：氢或卤素; n表示1或2; R3表示：被一个或多个卤素或C 1 -C 6烷基取代的苯基; 或环己基; 以及其治疗上可接受的盐或溶剂合物。 这些化合物可用作蛋白酶激活受体-1（PAR-1）拮抗剂，特别是治疗血栓形成。
-
-
-
-
-
-
-
-
-
搜索结果
21 条记录 (耗时 0.015 秒)
