发明申请
US20090176877A1 OSELTAMIVIR PHOSHATE GRANULE AND PREPARATION METHOD THEREOF
有权
OSELTAMIVIR PHOSHATE GRANULE及其制备方法
- 专利标题: OSELTAMIVIR PHOSHATE GRANULE AND PREPARATION METHOD THEREOF
- 专利标题(中): OSELTAMIVIR PHOSHATE GRANULE及其制备方法
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申请号: US12225935申请日: 2006-08-11
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公开(公告)号: US20090176877A1公开(公告)日: 2009-07-09
- 发明人: Song Li , Wu Zhong , Junhai Xiao , Yunde Xie , Xingzhou Li , Hao Cui , Zhibing Zheng
- 申请人: Song Li , Wu Zhong , Junhai Xiao , Yunde Xie , Xingzhou Li , Hao Cui , Zhibing Zheng
- 优先权: CN200610066995.7 20060404
- 国际申请: PCT/CN2006/002043 WO 20060811
- 主分类号: A61K31/215
- IPC分类号: A61K31/215
摘要:
The present invention relates to an oseltamivir phosphate granule and preparation method thereof. The said granule comprises 1.97-19.8 wt. % oseltamivir phosphate, 75.0-97.5 wt. % diluent, 0.1-5.0 wt. % binder, optionally 1.0-5.0 wt. % edible flavouring essence, sweetener and/or edible pigment. It is prepared by using 30-55 v/v % aqueous ethanol solution as moistening agent. The granules prepared by the formulation and method according to the present invention have good uniformity and stability and are water-soluble. The administration dosage of the granules can be conveniently selected based on the age and body weight of patients. The oseltamivir phosphate granule is suitable for administering to old people, children and flu gravis patients and those patients that swallow inconveniently or difficulty. The preparation of the granule is simple and low in production cost.