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    N-Substituted Thiomorpholine Derivatives as the Inhibitors of Dipeptidyl Peptidase IV and the Pharmaceutical Uses Thereof
    9.
    发明申请
    N-Substituted Thiomorpholine Derivatives as the Inhibitors of Dipeptidyl Peptidase IV and the Pharmaceutical Uses Thereof 有权
    N-取代的硫代吗啉衍生物作为二肽基肽酶IV的抑制剂及其药物用途

    公开(公告)号：US20100113433A1

    公开(公告)日：2010-05-06

    申请号：US12593717

    申请日：2007-06-01

    申请人： Song Li ,  Wu Zhong ,  Junhai Xiao ,  Xinghai Ma ,  Lili Wang ,  Hongying Liu ,  Zhibing Zheng

    发明人： Song Li ,  Wu Zhong ,  Junhai Xiao ,  Xinghai Ma ,  Lili Wang ,  Hongying Liu ,  Zhibing Zheng

    IPC分类号： A61K31/54 ,  C07D279/12 ,  A61P3/10 ,  A61P9/10

    CPC分类号： C07D295/185

    摘要： The present invention relates to N-Substituted thiomorpholine compounds of formula I, the possible isomers, the pharmaceutically acceptable salts, the solvates, the hydrates or the prodrugs thereof as inhibitors of dipeptidyl peptidase IV (DPP-IV); and to a method for preparing the compounds of formula I, pharmaceutical compositions comprising the compounds of formula I and use of the compounds of formula II in medical field, particularly in the preparation of medicaments for treating and preventing diabetes (in particular type II diabetes), hyperglycemia, X syndrome, hyperinsulinemia, obesity, atherosclerosis and all kinds of diseases modulated by immune system.

    摘要翻译： 本发明涉及式I的N-取代的硫代吗啉化合物，可能的异构体，其药学上可接受的盐，溶剂合物，水合物或其前药作为二肽基肽酶IV（DPP-IV）的抑制剂; 以及制备式I化合物的方法，包含式I化合物的药物组合物和医药领域中式II化合物的用途，特别是制备用于治疗和预防糖尿病（特别是II型糖尿病）的药物， ，高血糖症，X综合征，高胰岛素血症，肥胖，动脉粥样硬化以及免疫系统调节的各种疾病。