发明申请
- 专利标题: Carboxamide derivative and use thereof
- 专利标题(中): 羧酰胺衍生物及其用途
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申请号: US10584949申请日: 2005-01-13
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公开(公告)号: US20090186874A1公开(公告)日: 2009-07-23
- 发明人: Yoshinori Ikeura , Junya Shirai
- 申请人: Yoshinori Ikeura , Junya Shirai
- 优先权: JP2004-007373 20040114
- 国际申请: PCT/JP05/00627 WO 20050113
- 主分类号: A61K31/55
- IPC分类号: A61K31/55 ; C07D211/60 ; A61K31/445 ; A61K31/44 ; C07D213/81 ; C07D401/02 ; C07D401/12 ; C07D223/04 ; C07D401/00 ; A61K31/4545
摘要:
The present invention relates to a compound represented by the formula wherein ring A is a nitrogen-containing heterocycle optionally further having substituent(s), ring B and ring C are each an aromatic ring optionally having substituent(s), R1 is a hydrogen atom, a hydrocarbon group optionally having substituent(s), an acyl group or a heterocyclic group optionally having substituent(s), Z is an optionally halogenated C1-6 alkyl group, Y is a methylene group optionally having substituent(s), m and n are each an integer of 0 to 5, m+n is an integer of 2 to 5, and is a single bond or a double bond, or a salt thereof. The compound of the present invention has a superior tachykinin receptor antagonistic action, particularly an SP receptor antagonistic action, and is useful as a pharmaceutical agent, for example, a tachykinin receptor antagonist, an agent for the prophylaxis or treatment of an abnormality of lower urinary tract functions, a digestive organ disease or a central nerve disease, and the like.
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