发明申请
US20090186886A1 Tricyclic 1,2,4-Triazine Oxides and Compositions for Therapeutic Use in Cancer Treatments
有权
用于治疗癌症治疗的三环1,2,4-三嗪氧化物和组合物
- 专利标题： Tricyclic 1,2,4-Triazine Oxides and Compositions for Therapeutic Use in Cancer Treatments
- 专利标题（中）： 用于治疗癌症治疗的三环1,2,4-三嗪氧化物和组合物
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申请号： US11887368申请日： 2006-03-31
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公开(公告)号： US20090186886A1公开(公告)日： 2009-07-23
- 发明人: Michael Patrick Hay , Adrian Blaser , William Alexander Denny , Kevin Owen Hicks , Ho Huat Lee , Karin Pchalek , Frederik Bastiaan Pruijn , Bronwyn Gae Siim , William Robert Wilson , Shangjin Yang
- 申请人： Michael Patrick Hay , Adrian Blaser , William Alexander Denny , Kevin Owen Hicks , Ho Huat Lee , Karin Pchalek , Frederik Bastiaan Pruijn , Bronwyn Gae Siim , William Robert Wilson , Shangjin Yang
- 申请人地址： NZ Auckland
- 专利权人： Auckland Uniservices Limited
- 当前专利权人： Auckland Uniservices Limited
- 当前专利权人地址： NZ Auckland
- 优先权： NZ539152 20050331; NZ542556 20050922
- 国际申请： PCT/NZ2006/000064 WO 20060331
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; C07D253/10 ; A61K31/53 ; C07D413/06 ; C07D491/048 ; A61P35/00
摘要：
The invention relates to novel tricyclic 1,2,4-triazine-1-oxides and novel tricyclic 1,2,4-triazine-1,4-dioxides of formula I and to related analogues, to their preparation, and to their use as hypoxia-selective drugs and radiosensitizers for cancer therapy, both alone or in combination with radiation and/or other anticancer drugs.