发明申请
US20090186928A1 Novel crystalline forms of an inhibitor of 11-beta-hydroxysteroid dehydrogenase type 1
有权
11型β-羟基类固醇脱氢酶抑制剂的新型结晶形式
- 专利标题: Novel crystalline forms of an inhibitor of 11-beta-hydroxysteroid dehydrogenase type 1
- 专利标题(中): 11型β-羟基类固醇脱氢酶抑制剂的新型结晶形式
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申请号: US10587110申请日: 2005-01-21
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公开(公告)号: US20090186928A1公开(公告)日: 2009-07-23
- 发明人: Yuri Bereznitski , Mark A. Huffman , Joseph E. Lynch , Matthew Zhao
- 申请人: Yuri Bereznitski , Mark A. Huffman , Joseph E. Lynch , Matthew Zhao
- 国际申请: PCT/US05/01928 WO 20050121
- 主分类号: A61K31/4196
- IPC分类号: A61K31/4196 ; C07D249/08 ; A61P3/10
摘要:
Novel crystalline salts of 3-[1-(4-chlorophenyl)-trans-3-fluorocyclobutyl]-4,5-dicyclopropyl-r-4H-1,2,4-triazole are potent inhibitors of 11β-hydroxysteroid dehydrogenase Type 1 and are useful for the treatment of conditions associated with Metabolic Syndrome as well as cognitive impairment. The invention also relates to pharmaceutical compositions containing these novel salts, processes to prepare these salts and their pharmaceutical compositions as well as uses thereof for the treatment of Type 2 diabetes, hyperglycemia, obesity, dyslipidemia, hypertension, and cognitive impairment.
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