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公开(公告)号:US20230133132A1
公开(公告)日:2023-05-04
申请号:US17798296
申请日:2021-02-05
申请人: Cytokinetics, Inc.
IPC分类号: C07D295/073 , C07D211/60 , C07D233/64 , C07D231/12 , C07C275/42 , C07C275/40 , C07D487/04 , C07D241/12 , C07D241/38 , C07D207/08 , C07D207/06 , C07D307/16 , C07D309/14 , C07D487/08 , C07D305/08 , C07D335/02 , C07D205/04 , C07D491/107 , C07D333/08 , C07D331/04 , C07D471/08 , C07D487/10 , C07D271/10 , C07D261/08 , C07D401/04 , C07D471/10 , C07D405/04 , C07D209/52 , C07D401/06 , C07D403/06 , C07D243/08 , C07D237/08 , C07D275/02 , C07D305/14 , C07D497/10 , C07D498/10 , C07D263/30 , C07D491/08 , C07D279/12 , C07D249/08
摘要: Provided are compounds of Formula (II) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, and p are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (II), or a pharmaceutically acceptable salt thereof. Also provided are methods of using a compound of Formula (II), or a pharmaceutically acceptable salt thereof.
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公开(公告)号:US11634392B2
公开(公告)日:2023-04-25
申请号:US17064447
申请日:2020-10-06
IPC分类号: C07D249/08 , B01D3/40 , A01N43/653 , C07B63/00
摘要: A high yielding extraction process for the purification of N-(2,4-dichloro-5-(4-(difluoromethyl)-3-methyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)methanesulfonamide (sulfentrazone) by selectively partitioning the desired product from the crude mixture, thereby increasing its purity by decreasing the presence of unwanted impurities and improving the color and particle size distribution of the final sulfentrazone product. The selective partitioning is achieved by the sequential use of an organic solvent, water, aqueous inorganic base and a concentrated aqueous inorganic acid.
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3.
公开(公告)号:US11632957B2
公开(公告)日:2023-04-25
申请号:US16794955
申请日:2020-02-19
发明人: Ronald J. Heemstra , Ronald Ross, Jr. , Kyle A. DeKorver , Kaitlyn Gray , Daniel I. Knueppel , Peter Vednor , Timothy P. Martin , Joseph D. Eckelbarger , John F. Daeuble, Sr. , Ricky Hunter , David A. Demeter , Tony K. Trullinger , Erich W. Baum , Zoltan L. Benko , Nakyen Choy , Gary D. Crouse , Fangzheng Li , Jeffrey Nissen , Monica B. Olson , Michelle Riener , Thomas C. Sparks , Frank J. Wessels , Maurice C. Yap
IPC分类号: A01N53/00 , C07C255/46 , C07C255/57 , C07C255/60 , C07C259/10 , C07D213/84 , C07D213/89 , C07D215/227 , C07C271/28 , C07C271/66 , C07D215/38 , C07D231/56 , C07D233/36 , C07C311/08 , C07C311/46 , C07D235/30 , C07C317/28 , C07C317/40 , C07C317/50 , C07C323/41 , C07C323/42 , C07C323/59 , C07C331/12 , C07C381/10 , C07D205/04 , C07C237/42 , C07D207/452 , C07C255/29 , C07D209/49 , C07D213/75 , C07D213/81 , C07D309/14 , C07D231/12 , C07D331/04 , C07D333/36 , C07D249/08 , C07D207/10 , C07D285/06 , C07D295/32 , C07D305/08 , C07D207/273 , C07D233/80 , C07D261/12 , C07D263/26 , C07D277/36 , C07D307/33 , C07D333/48 , C07C237/22 , C07D213/56 , C07D277/30 , C07D307/52 , C07D333/60 , A01N37/22 , A01N37/34 , A01N41/10 , A01N43/40 , A01N43/60 , A01N43/653 , A01N43/707 , A01N43/82 , A01N43/90 , C07C233/63 , C07C233/65 , C07C317/14 , C07D241/20 , C07D253/07 , C07D487/04
摘要: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).
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公开(公告)号:US11584714B2
公开(公告)日:2023-02-21
申请号:US16425791
申请日:2019-05-29
申请人: Omeros Corporation
发明人: Neil S. Cutshall , Jennifer Lynn Gage , Franz A. Gruswitz , Juhienah Khalaf , Thomas L. Little , Markus Metz , Jeremiah H. Nguyen , Peter Kurt Nollert von Specht , Jennifer Tsoung , Michael Cicirelli , Sara Rebecca Goldstein , Santosh Kumar Keshipeddy , Do Yeon Kwon , Robert Huerta Lemus , Sudheer Babu Vaddela
IPC分类号: C07D211/60 , A61K31/445 , C07D205/04 , C07D239/96 , C07D401/12 , C07D217/14 , C07C251/24 , C07D213/73 , C07D239/94 , C07D235/30 , C07D207/24 , C07D295/135 , C07C235/88 , C07D295/033 , C07D257/04 , C07D207/16 , C07D207/36 , C07D295/26 , C07D213/81 , C07D417/12 , C07D277/56 , C07D231/44 , C07D471/04 , C07D233/64 , C07D403/12 , C07D249/08 , C07D401/14 , C07D417/14 , C07D471/06 , C07D413/12 , C07D409/14 , C07D495/04 , C07D409/10 , C07D413/14 , C07D401/06 , C07D403/06
摘要: The present disclosure provides, inter alia, compounds with MASP-2 inhibitory activity, compositions of such compounds and methods of making and using such compounds.
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公开(公告)号:US11524938B2
公开(公告)日:2022-12-13
申请号:US17067434
申请日:2020-10-09
发明人: Stefan Werner , Stefanie Mesch , Arwed Cleve , Nico Bräuer , Simon Anthony Herbert , Markus Koch , Henrik Dahllöf , Maren Osmers , Elizabeth Hardaker , Anton Lishchynskyi
IPC分类号: C07D213/64 , C07D403/06 , C07D231/14 , C07D231/16 , C07D231/18 , C07D233/61 , C07D233/64 , C07D233/68 , C07D401/04 , C07D403/04 , C07D405/06 , C07D239/34 , C07D249/06 , C07D249/08 , C07D249/14 , C07D471/04 , C07D261/08 , C07D271/06 , C07C311/46 , C07F5/02 , C07D207/416 , C07D231/56 , C07D213/85 , C07D277/56 , C07D249/20 , C07D213/60 , C07C311/17 , C07D213/61 , C07D239/30 , C07D239/42 , C07D249/10 , C07D213/65 , C07D249/12 , C07D233/16 , C07C323/62 , C07D237/08 , C07D213/40 , C07D239/26 , C07D235/06 , C07C311/40 , C07D213/74 , C07D405/04 , C07D271/04 , C07D277/26 , C07D249/18 , C07D277/34 , C07D275/02 , C07D263/32 , C07D231/38 , C07D207/333 , A61P29/00 , C07D235/08 , C07D401/12 , C07D231/12
摘要: Substituted aromatic sulfonamides of formula (I) pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease.
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公开(公告)号:US11504346B2
公开(公告)日:2022-11-22
申请号:US16200286
申请日:2018-11-26
发明人: Elisa Tomat , Tsuhen Chang , Eman A. Akam
IPC分类号: A61K31/175 , C07D307/64 , C07D249/08 , C07C337/04 , C07D277/36
摘要: Compositions of pro-chelator compounds are described herein. The pro-chelators may be activated in reducing conditions, such as in the intracellular space, so as to sequester metals such as iron. The pro-chelators may be used to target malignant cells or in the treatment in a condition associated with metal ion disregulation.
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公开(公告)号:US11492335B2
公开(公告)日:2022-11-08
申请号:US17104557
申请日:2020-11-25
申请人: YUHAN CORPORATION
发明人: Tae Dong Han , Hee Jae Tak , Eun Kyung Kim , Su Bin Choi , Dong Hoon Kim , Sol Park , Eun Hye Jung , Hyun Ho Choi , Tae Wang Kim , Mi Kyeong Ju , Na Ry Ha
IPC分类号: C07D401/14 , C07D403/04 , C07D403/14 , C07D409/10 , C07D413/14 , C07D417/04 , C07D417/14 , C07D249/08 , C07D401/04 , C07D405/10 , C07D407/14 , C07D401/10 , C07D403/10 , C07D405/14 , C07D413/10 , C07D417/10 , C07D249/12
摘要: The present technology provides aryl or heteroaryl triazolone derivatives or pharmaceutically acceptable salts thereof, preparation processes thereof, pharmaceutical compositions comprising the same, and the use thereof. The aryl or heteroaryl triazolone derivatives or their pharmaceutically acceptable salts exhibit selective inhibitory activity on VAP-1 and therefore can be usefully applied, e.g., for the treatment and prophylaxis of nonalcoholic hepatosteatosis (NASH).
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8.
公开(公告)号:US20220348550A1
公开(公告)日:2022-11-03
申请号:US17629254
申请日:2020-11-16
发明人: Yinan CHENG , Honglian LI , Xianru GUO , Zhenhua JIANG , Ziyang SU , Mengmeng ZHANG , Liansheng SUN , Guofu SHEN , Yichao MA
IPC分类号: C07D249/08 , A01P3/00 , A01N43/653
摘要: Disclosed in the present invention are a 2-(1,2,4-triazolyl)benzoyl arylamine active compound for inhibiting a wheat take-all pathogen, and a preparation method therefor. The active compound has a structure as shown in formula I. R1, R3, and R4 are —H, —F, —Cl, —Br, —I, —CN, —NO2, —CF3, —CHO, —C1-C4 alkyl groups, or —C1-C4 haloalkyl groups, or —O—R5; R2 is —H, —F, —Cl, —Br, —I, —CN, —CF3, —CHO, —C1-C4 alkyl groups, or —C1-C4 haloalkyl groups, or —O—R5; X is —F, —Cl, —Br, —I, —CN, —NO2, —CF3, or —COOR6; Y is —H, —F, —Cl, —Br, —I, —CN, —NO2, —CF3, or —COOR6; R5 is —C1-C4 alkyl groups, or —C1-C4 haloalkyl groups; R6 is —C1-C4 alkyl groups, or —C1-C4 haloalkyl groups. The compound I has an excellent inhibition effect on the wheat take-all pathogen and can be applied to prevention and treatment of wheat take-all.
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公开(公告)号:US20220324806A1
公开(公告)日:2022-10-13
申请号:US17626516
申请日:2020-07-10
IPC分类号: C07D213/30 , C07D307/42 , C07C39/24 , C07D239/26 , C07D333/16 , C07D231/12 , C07D333/56 , C07D261/08 , C07C255/53 , C07D257/04 , C07C43/225 , C07D295/033 , C07C43/205 , C07D271/06 , C07D271/113 , C07D249/08 , C07D207/333 , C07D277/26 , C07D209/12 , C07D235/18 , C07D473/00 , C07D305/06 , C07D303/14 , C07D203/10 , C07D263/14 , C07D309/32 , C07D241/12
摘要: The current application relates to cannabinoid derivatives of formula (I) and pharmaceutical compositions comprising the same. The cannabinoid derivative can be used for the treatment of diseases associated with cannabinoid receptor such as pain, ADHD/ADD, alcohol use disorder, anxiety disorder, and dementias.
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公开(公告)号:US11447453B2
公开(公告)日:2022-09-20
申请号:US16817209
申请日:2020-03-12
发明人: Nicholas David Peter Cosford , Dhanya Raveendra-Panickar , Douglas J. Sheffler , John Howard Hutchinson , Reto Andreas Gadient
IPC分类号: C07D277/20 , C07D285/08 , C07D249/08 , A61K31/426 , A61K31/433 , A61K31/4196 , A61P25/00 , C07D243/14 , A61K31/427 , C07D217/06 , C07D417/04 , C07D403/12 , C07D233/54 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/10 , C07D405/04 , C07D239/26 , C07D409/04 , C07D243/12 , C07D271/06 , C07D275/02 , C07D277/30 , A61K31/505 , A61K31/506 , C07D231/12 , C07D233/64 , C07D261/08 , C07D263/32 , C07D277/26 , C07D307/38 , C07D333/24 , C07D401/14 , C07D405/10 , C07D409/02 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/10 , C07D417/14
摘要: Provided herein are small molecule active metabotropic glutamate subtype-2 and -3 receptor negative allosteric modulators (NAMs), compositions comprising the compounds, and methods of using the compounds and compositions.
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