发明申请
US20090203627A1 Specific binding sites in collagen for integrins and use thereof
有权
用于整联蛋白的胶原中的特异性结合位点及其用途
- 专利标题： Specific binding sites in collagen for integrins and use thereof
- 专利标题（中）： 用于整联蛋白的胶原中的特异性结合位点及其用途
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申请号： US12383746申请日： 2009-03-26
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公开(公告)号： US20090203627A1公开(公告)日： 2009-08-13
- 发明人: Magnus Hook , Xuejun Xu , Jiyeun Kim
- 申请人： Magnus Hook , Xuejun Xu , Jiyeun Kim
- 主分类号： A61K38/08
- IPC分类号： A61K38/08 ; C12N15/63 ; C12N5/10 ; G01N33/566 ; C07K7/06 ; C07K19/00 ; C12N5/06
摘要：
The present invention identified a high affinity binding sequence in collagen type III for the collagen-binding integrin I domains. Provided herein are the methods used to characterize the sequence, the peptides comprising this novel sequence and the use of the peptides in enabling cell adhesion. Also provided herein are methods to identify specific integrin inhibitors, sequences of these inhibitors and their use in inhibiting pathophysiological conditions that may arise due to integrin-collagen interaction.
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