发明申请
US20090203912A1 Regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles
有权
苯并咪唑和氮杂苯并咪唑的区域选择性钯催化合成
- 专利标题： Regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles
- 专利标题（中）： 苯并咪唑和氮杂苯并咪唑的区域选择性钯催化合成
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申请号： US12353271申请日： 2009-01-14
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公开(公告)号： US20090203912A1公开(公告)日： 2009-08-13
- 发明人: Jorge ALONSO , Andreas LINDENSCHMIDT , Marc NAZARE , Nis HALLAND , Omar RKYEK , Matthias URMANN
- 申请人： Jorge ALONSO , Andreas LINDENSCHMIDT , Marc NAZARE , Nis HALLAND , Omar RKYEK , Matthias URMANN
- 申请人地址： FR Paris
- 专利权人： SANOFI-AVENTIS
- 当前专利权人： SANOFI-AVENTIS
- 当前专利权人地址： FR Paris
- 优先权： EP06014789.9 20060715; EPPCT/EP2007/005816 20070630
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; C07D235/08
摘要：
The present invention relates to a process for the regioselective synthesis of compounds of the formula I, wherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct palladium catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides useful for the production of pharmaceuticals, diagnostic agents, liquid crystals, polymers, herbicides, fungicidals, nematicidals, parasiticides, insecticides, acaricides and arthropodicides.
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