发明申请
US20090208534A1 ATTENUATED SALMONELLA AS A DELIVERY SYSTEM FOR SIRNA-BASED TUMOR THERAPY
审中-公开
作为用于基于SIRNA的肿瘤治疗的递送系统的衰减的SALMONELLA
- 专利标题： ATTENUATED SALMONELLA AS A DELIVERY SYSTEM FOR SIRNA-BASED TUMOR THERAPY
- 专利标题（中）： 作为用于基于SIRNA的肿瘤治疗的递送系统的衰减的SALMONELLA
-
申请号： US12374916申请日： 2007-07-24
-
公开(公告)号： US20090208534A1公开(公告)日： 2009-08-20
- 发明人: Deqi Xu , Dennis J. Kopecko , Jiadi Hu , Ling Zhang , Xuejian Zhao , Lifang Gao
- 申请人： Deqi Xu , Dennis J. Kopecko , Jiadi Hu , Ling Zhang , Xuejian Zhao , Lifang Gao
- 申请人地址： US MD Rockville
- 专利权人： The Government of The United States of America, as represented by the Secretary, Dept.of Health
- 当前专利权人： The Government of The United States of America, as represented by the Secretary, Dept.of Health
- 当前专利权人地址： US MD Rockville
- 优先权： CN200610017045.5 20060726
- 国际申请： PCT/US07/74272 WO 20070724
- 主分类号： A61K39/112
- IPC分类号： A61K39/112 ; C12N1/20 ; A61P35/00
摘要：
The invention relates to an attenuated Salmonella sp. that is capable of targeting a solid tumor when administered in vivo comprising a short hairpin (sh) RNA construct, and methods of inhibiting the growth or reducing the volume of a solid tumor cancer comprising administering an effective amount of an attenuated Salmonella sp. to a patient having a solid tumor cancer, wherein said attenuated Salmonella sp. is a tumor targeting attenuated Salmonella sp. expressing a short hairpin (sh) RNA which attenuated Salmonella sp. is capable of inhibiting the growth or reducing the volume of the solid tumor cancer when administered in vivo.
公开/授权文献
- US1224561A Automobile-jack. 公开/授权日：1917-05-01
信息查询
