发明申请
US20090209620A1 Direct Reversal Of The Suppressive Function Of CD4+Regulatory T Cells Via Toll-Like Receptor 8 Signaling
审中-公开
通过Toll样受体8信号直接逆转CD4 +调节性T细胞的抑制功能
- 专利标题： Direct Reversal Of The Suppressive Function Of CD4+Regulatory T Cells Via Toll-Like Receptor 8 Signaling
- 专利标题（中）： 通过Toll样受体8信号直接逆转CD4 +调节性T细胞的抑制功能
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申请号： US11816902申请日： 2006-03-09
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公开(公告)号： US20090209620A1公开(公告)日： 2009-08-20
- 发明人: Rong-Fu Wang , Guangyon Peng , Yicheng Wang
- 申请人： Rong-Fu Wang , Guangyon Peng , Yicheng Wang
- 国际申请： PCT/US2006/008379 WO 20060309
- 主分类号： A61K31/7088
- IPC分类号： A61K31/7088 ; C12N5/06 ; C12Q1/02 ; C40B30/06
摘要：
CD4+ regulatory T (Treg) cells profoundly suppress host immune responses and thus protect against autoimmune disease while restricting desired immune responses such as antitumor immunity. Synthetic phosphorothioate-protected, guanosine-containing oligonucleotides can directly reverse the suppressive activity of Treg cells without involving dendritic cells. This effect appears to be transduced by signaling through Toll-like receptor (TLR) 8 and engagement of the MyD88 and IRAK4 molecules in Treg cells. Stimulation of Treg cells with natural ligands for human TLR8 recapitulated the effect of the synthetic guanosine-containing oligonucleotides .
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