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    Direct Reversal Of The Suppressive Function Of CD4+Regulatory T Cells Via Toll-Like Receptor 8 Signaling
    1.
    发明申请
    Direct Reversal Of The Suppressive Function Of CD4+Regulatory T Cells Via Toll-Like Receptor 8 Signaling 审中-公开
    通过Toll样受体8信号直接逆转CD4 +调节性T细胞的抑制功能

    公开(公告)号：US20090209620A1

    公开(公告)日：2009-08-20

    申请号：US11816902

    申请日：2006-03-09

    申请人： Rong-Fu Wang ,  Guangyon Peng ,  Yicheng Wang

    发明人： Rong-Fu Wang ,  Guangyon Peng ,  Yicheng Wang

    IPC分类号： A61K31/7088 ,  C12N5/06 ,  C12Q1/02 ,  C40B30/06

    CPC分类号： C12N15/113 ,  C12N15/1138 ,  C12N15/117 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/17 ,  C12N2310/315

    摘要： CD4+ regulatory T (Treg) cells profoundly suppress host immune responses and thus protect against autoimmune disease while restricting desired immune responses such as antitumor immunity. Synthetic phosphorothioate-protected, guanosine-containing oligonucleotides can directly reverse the suppressive activity of Treg cells without involving dendritic cells. This effect appears to be transduced by signaling through Toll-like receptor (TLR) 8 and engagement of the MyD88 and IRAK4 molecules in Treg cells. Stimulation of Treg cells with natural ligands for human TLR8 recapitulated the effect of the synthetic guanosine-containing oligonucleotides .

    摘要翻译： CD4 +调节T（Treg）细胞深刻地抑制宿主免疫应答，从而防止自身免疫疾病，同时限制所需的免疫应答如抗肿瘤免疫。 合成的硫代磷酸酯保护的含鸟苷酸寡核苷酸可以直接逆转Treg细胞的抑制活性而不涉及树突状细胞。 该效应似乎通过Toll样受体（TLR）8的信号转导和MyD88和IRAK4分子在Treg细胞中的结合来转导。 人TLR8天然配体对Treg细胞的刺​​激重现了含有合成含鸟苷酸的寡核苷酸的作用。

    REVERSAL OF THE SUPPRESSIVE FUNCTION OF SPECIFIC T CELLS VIA TOLL-LIKE RECEPTOR 8 SIGNALING
    2.
    发明申请
    REVERSAL OF THE SUPPRESSIVE FUNCTION OF SPECIFIC T CELLS VIA TOLL-LIKE RECEPTOR 8 SIGNALING 审中-公开
    特异性T细胞通过类似受体8信号的抑制功能的反转

    公开(公告)号：US20080026986A1

    公开(公告)日：2008-01-31

    申请号：US11757235

    申请日：2007-06-01

    申请人： Rong-Fu Wang ,  Guangyong Peng ,  Yicheng Wang

    发明人： Rong-Fu Wang ,  Guangyong Peng ,  Yicheng Wang

    IPC分类号： A61K31/7042 ,  A61K38/02 ,  A61P35/00

    CPC分类号： A61K31/7042 ,  C12N15/115 ,  C12N15/117

    摘要： CD8+ regulatory T (Treg) cells and γδ Treg cells profoundly suppress host immune responses and thus protect against autoimmune disease while restricting desired immune responses such as antitumor immunity. Synthetic phosphorothioate-protected, guanosine-containing oligonucleotides can directly reverse the suppressive activity of Treg cells without involving dendritic cells. This effect appears to be transduced by signaling through Toll-like receptor (TLR) 8 and engagement of the MyD88 and IRAK4 molecules in Treg cells, in specific embodiments. Stimulation of Treg cells with natural ligands for human TLR8 recapitulated the effect of the synthetic guanosine-containing oligonucleotides.

    摘要翻译： CD8 + Treg细胞和Gammadelta Treg细胞深刻地抑制宿主免疫应答，从而防止自身免疫疾病，同时限制所需的免疫应答如抗肿瘤免疫。 合成的硫代磷酸酯保护的含鸟苷酸寡核苷酸可以直接逆转Treg细胞的抑制活性而不涉及树突状细胞。 在特定的实施方案中，这种作用似乎通过Toll样受体（TLR）8的信号转导和MyD88和IRAK4分子在Treg细胞中的接合而转导。 人TLR8天然配体对Treg细胞的刺​​激重现了含有合成含鸟苷酸的寡核苷酸的作用。