发明申请
US20090232854A1 USES OF BISPECIFIC ANTIBODY COATED DENDRITIC CELLS PULSED WITH ANTIGENS AND GM-CSF IN IMMUNE REGULATION
审中-公开
在免疫调节中用抗原和GM-CSF刺激的双重抗体包被的DENDRITIC细胞的使用
- 专利标题： USES OF BISPECIFIC ANTIBODY COATED DENDRITIC CELLS PULSED WITH ANTIGENS AND GM-CSF IN IMMUNE REGULATION
- 专利标题（中）： 在免疫调节中用抗原和GM-CSF刺激的双重抗体包被的DENDRITIC细胞的使用
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申请号： US12401089申请日： 2009-03-10
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公开(公告)号： US20090232854A1公开(公告)日： 2009-09-17
- 发明人: Bellur S. Prabhakar , Mark J. Holterman , Chenthamarakshan Vasu , Matthew N. Meriggioli
- 申请人： Bellur S. Prabhakar , Mark J. Holterman , Chenthamarakshan Vasu , Matthew N. Meriggioli
- 申请人地址： US IL Urbana
- 专利权人： The Board of Trustees of the University of Illinois
- 当前专利权人： The Board of Trustees of the University of Illinois
- 当前专利权人地址： US IL Urbana
- 主分类号： A61K9/00
- IPC分类号： A61K9/00 ; A61K35/12 ; A61P37/06
摘要：
GM-CSF administered before immunization exerted a sustained suppressive effect against the induction of myasthenia gravis (MG). This suppression was associated with lowered serum autoantibody levels, reduced T cell proliferative responses to AChR, and an expansion in the population of FoxP3+ regulatory T cells. Manipulating DCs to expand regulatory T cells is useful for the control of autoimmune diseases such as myasthenia gravis MG.
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