- 专利标题: 2-AMINOBENZAMIDE DERIVATIVE
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申请号: US12094298申请日: 2006-11-29
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公开(公告)号: US20090233900A1公开(公告)日: 2009-09-17
- 发明人: Takahiro Kuramochi , Ryoji Hirabayashi , Yohei Koganemaru , Ryosuke Munakata , Koichi Yonezawa , Tetsuo Kiso
- 申请人: Takahiro Kuramochi , Ryoji Hirabayashi , Yohei Koganemaru , Ryosuke Munakata , Koichi Yonezawa , Tetsuo Kiso
- 申请人地址: JP Chuo-ku, Tokyo
- 专利权人: Astellas Pharma Inc.
- 当前专利权人: Astellas Pharma Inc.
- 当前专利权人地址: JP Chuo-ku, Tokyo
- 优先权: JP2005-345502 20051130
- 国际申请: PCT/JP2006/323863 WO 20061129
- 主分类号: A61K31/536
- IPC分类号: A61K31/536 ; C07D265/30 ; A61K31/535 ; C07D405/04 ; A61K31/497 ; C07D413/00 ; A61K31/5377 ; C07D265/36 ; A61K31/397
摘要:
To provide a novel and excellent agent for treating or preventing nociceptive pain, neuropathic pain, cancer pain, headache, bladder function disorder and the like, based on the inhibitory action on the capsaicin receptor VR1 activation.The present invention was accomplished by confirming that a benzamide derivative characterized by the possession of a benzene ring in which a single ring is condensed on the nitrogen atom of amido group and possession of a lower alkylamino or an amino group substituted with a ring group at the neighboring position of said amido group has a strong inhibitory action on VR1 activation and excellent pharmacological actions based on this and by finding that it can become an excellent agent for treating or preventing VR1-involved diseases such as nociceptive pain, neuropathic pain, cancer pain, headache, bladder function disorder and the like.
公开/授权文献
- US08106190B2 2-aminobenzamide derivatives 公开/授权日:2012-01-31