发明申请
- 专利标题： THIOPHENECARBOXAMIDE DERIVATIVES AS EP4 RECEPTOR LIGANDS
- 专利标题（中）： 硫代酰胺衍生物作为EP4受体配体
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申请号： US12309941申请日： 2007-08-10
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公开(公告)号： US20090247596A1公开(公告)日： 2009-10-01
- 发明人: Marc Blouin , Jason Burch , Yongxin Han , Christophe Mellon
- 申请人： Marc Blouin , Jason Burch , Yongxin Han , Christophe Mellon
- 国际申请： PCT/CA2007/001404 WO 20070810
- 主分类号： A61K31/41
- IPC分类号： A61K31/41 ; C07D333/22 ; A61K31/381 ; C07D409/12 ; A61P29/00
摘要：
The invention is directed to thiophenecarboxamide derivatives of formulae I and II as EP4 receptor ligands, antagonists or agonists, useful for the treatment of EP4 mediated diseases or conditions, such as acute and chronic pain, osteoarthritis, rheumatoid arthritis, cancer and glaucoma. Pharmaceutical compositions and methods of use are also included. (Formulas I and II).
公开/授权文献
- US08969394B2 Thiophenecarboxamide derivatives as EP4 receptor ligands 公开/授权日：2015-03-03
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