发明申请
- 专利标题： dsRNA COMPOSITIONS AND METHODS FOR TREATING HPV INFECTION
- 专利标题（中）： dsRNA组合物和治疗HPV感染的方法
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申请号： US12294388申请日： 2007-03-23
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公开(公告)号： US20090247607A1公开(公告)日： 2009-10-01
- 发明人: John Benson , Birgit Bramlage , Kevin Fitzgerald , Pamela Tan , Hans-Peter Vornlocher
- 申请人： John Benson , Birgit Bramlage , Kevin Fitzgerald , Pamela Tan , Hans-Peter Vornlocher
- 国际申请： PCT/US07/07241 WO 20070323
- 主分类号： A61K31/713
- IPC分类号： A61K31/713 ; C07H21/02 ; C12N5/10 ; C12N15/74 ; A61P31/12
摘要：
The invention relates to a double-stranded ribonucleic acid (dsRNA) for treating human papilloma virus (HPV) infection. The dsRNA comprises an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of an HPV Target gene selected from among HPV E1, HPV E6 and the human E6AP gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by HPV infection and the expression of the E6AP gene using the pharmaceutical composition; and methods for inhibiting the expression of the HPV Target genes in a cell.
公开/授权文献
- US07956177B2 dsRNA compositions and methods for treating HPV infection 公开/授权日：2011-06-07