-
公开(公告)号：US07956177B2
公开(公告)日：2011-06-07
申请号：US12294388
申请日：2007-03-23
IPC分类号： C07H21/04
CPC分类号： C12N15/1137 , C12N15/111 , C12N15/1131 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3515 , C12N2320/31 , C12N2310/3521
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for treating human papilloma virus (HPV) infection. The dsRNA comprises an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of an HPV Target gene selected from among HPV E1, HPV E6 and the human E6AP gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by HPV infection and the expression of the E6AP gene using the pharmaceutical composition; and methods for inhibiting the expression of the HPV Target genes in a cell.
摘要翻译： 本发明涉及用于治疗人乳头瘤病毒（HPV）感染的双链核糖核酸（dsRNA）。 dsRNA包含具有长度小于30个核苷酸的核苷酸序列的反义链，其长度通常为19-25个核苷酸，并且与选自HPV E1，HPV E6中的HPV靶基因的至少一部分基本互补 和人类E6AP基因。 本发明还涉及包含dsRNA与药学上可接受的载体的药物组合物; 用于治疗由HPV感染引起的疾病和使用该药物组合物表达E6AP基因的方法; 以及抑制细胞中HPV靶基因表达的方法。
-
公开(公告)号：US20100249052A1
公开(公告)日：2010-09-30
申请号：US12593202
申请日：2008-03-25
IPC分类号： C12N15/86 , C07H21/02 , A61K31/7088
CPC分类号： C12N15/1137 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3515 , C12Y603/02019 , C12N2310/3521
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for treating human papilloma virus (HPV) infection. The dsRNA comprises an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of an HPV Target gene selected from the human E6AP gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by HPV infection and the expression of the E6AP gene using the pharmaceutical composition; and methods for inhibiting the expression of the HPV Target genes in a cell.
摘要翻译： 本发明涉及用于治疗人乳头瘤病毒（HPV）感染的双链核糖核酸（dsRNA）。 dsRNA包含具有长度小于30个核苷酸的核苷酸序列的反义链，其长度通常为19-25个核苷酸，并且其与至少一部分选自人E6AP基因的HPV靶基因互补。 本发明还涉及包含dsRNA与药学上可接受的载体的药物组合物; 用于治疗由HPV感染引起的疾病和使用该药物组合物表达E6AP基因的方法; 以及抑制细胞中HPV靶基因表达的方法。
-
公开(公告)号：US20090247607A1
公开(公告)日：2009-10-01
申请号：US12294388
申请日：2007-03-23
IPC分类号： A61K31/713 , C07H21/02 , C12N5/10 , C12N15/74 , A61P31/12
CPC分类号： C12N15/1137 , C12N15/111 , C12N15/1131 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3515 , C12N2320/31 , C12N2310/3521
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for treating human papilloma virus (HPV) infection. The dsRNA comprises an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of an HPV Target gene selected from among HPV E1, HPV E6 and the human E6AP gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by HPV infection and the expression of the E6AP gene using the pharmaceutical composition; and methods for inhibiting the expression of the HPV Target genes in a cell.
摘要翻译： 本发明涉及用于治疗人乳头瘤病毒（HPV）感染的双链核糖核酸（dsRNA）。 dsRNA包含具有长度小于30个核苷酸的核苷酸序列的反义链，其长度通常为19-25个核苷酸，并且与选自HPV E1，HPV E6中的HPV靶基因的至少一部分基本互补 和人类E6AP基因。 本发明还涉及包含dsRNA与药学上可接受的载体的药物组合物; 用于治疗由HPV感染引起的疾病和使用该药物组合物表达E6AP基因的方法; 以及抑制细胞中HPV靶基因表达的方法。
-
公开(公告)号：US20110230546A1
公开(公告)日：2011-09-22
申请号：US13116947
申请日：2011-05-26
CPC分类号： C12N15/1137 , C12N15/111 , C12N15/1131 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3515 , C12N2320/31 , C12N2310/3521
摘要： The invention relates to a double-stranded ribonucleic acid (dsRNA) for treating human papilloma virus (HPV) infection. The dsRNA comprises an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of an HPV Target gene selected from among HPV E1, HPV E6 and the human E6AP gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by HPV infection and the expression of the E6AP gene using the pharmaceutical composition; and methods for inhibiting the expression of the HPV Target genes in a cell.
摘要翻译： 本发明涉及用于治疗人乳头瘤病毒（HPV）感染的双链核糖核酸（dsRNA）。 dsRNA包含具有长度小于30个核苷酸的核苷酸序列的反义链，其长度通常为19-25个核苷酸，并且与选自HPV E1，HPV E6中的HPV靶基因的至少一部分基本互补 和人类E6AP基因。 本发明还涉及包含dsRNA与药学上可接受的载体的药物组合物; 用于治疗由HPV感染引起的疾病和使用该药物组合物表达E6AP基因的方法; 以及抑制细胞中HPV靶基因表达的方法。
-
公开(公告)号：US10338203B2
公开(公告)日：2019-07-02
申请号：US13229408
申请日：2011-09-09
申请人： Liexiang Fan , Paul Freiburger , John Benson
发明人： Liexiang Fan , Paul Freiburger , John Benson
摘要： Classification preprocessing is provided for medical ultrasound shear wave imaging. In response to stress, the displacement at one or more locations in a patient is measured. The displacement over time is a curve representing a shift in location. One or more characteristics of the curve, such as signal-to-noise ratio and maximum displacement, are used to classify the location. The location is classified as fluid or fluid tissue, solid tissue, or non-determinative. Subsequent shear imaging may provide shear information for locations of solid tissue and not at other locations.
-
公开(公告)号：US20130066204A1
公开(公告)日：2013-03-14
申请号：US13229408
申请日：2011-09-09
申请人： Liexiang Fan , Paul Freiburger , John Benson
发明人： Liexiang Fan , Paul Freiburger , John Benson
IPC分类号： A61B8/00
CPC分类号： G01S7/52036 , A61B8/0858 , A61B8/14 , A61B8/485 , A61B8/5207 , A61B8/5223 , G01S7/52022 , G03B42/06
摘要： Classification preprocessing is provided for medical ultrasound shear wave imaging. In response to stress, the displacement at one or more locations in a patient is measured. The displacement over time is a curve representing a shift in location. One or more characteristics of the curve, such as signal-to-noise ratio and maximum displacement, are used to classify the location. The location is classified as fluid or fluid tissue, solid tissue, or non-determinative. Subsequent shear imaging may provide shear information for locations of solid tissue and not at other locations.
摘要翻译： 为医学超声剪切波成像提供分类预处理。 响应于应力，测量患者中一个或多个位置处的位移。 时间上的位移是表示位置偏移的曲线。 使用曲线的一个或多个特征，例如信噪比和最大位移，用于对位置进行分类。 该位置被分类为流体或流体组织，固体组织或非决定性的。 随后的剪切成像可以为固体组织的位置提供剪切信息，而不是在其他位置。
-
公开(公告)号：US20050085411A1
公开(公告)日：2005-04-21
申请号：US10744964
申请日：2003-12-23
申请人： Peter Howley , John Benson , Hiroaki Kasukawa
发明人： Peter Howley , John Benson , Hiroaki Kasukawa
IPC分类号： A61K38/00 , A61K48/00 , C07K14/025 , G01N33/50 , G01N33/68 , A61K38/16 , A61K38/06 , A61K38/08 , A61K38/10
CPC分类号： G01N33/5011 , A61K38/00 , A61K48/00 , C07K14/005 , C07K2319/00 , C12N2710/20022 , G01N33/5008 , G01N33/502 , G01N33/5044 , G01N33/68
摘要： By virtue of the present invention, there is provided methods and compositions for interfering with the proliferation of cells infected and/or transformed by papillomaviruses. The processes and compositions of this invention may be used to treat any mammal, including humans. According to this invention, mammals are treated by the pharmaceutically acceptable administration of an E2 peptidomimetic to reduce the symptoms of the specific papillomavirus-associated disease, or to prevent their recurrence.
摘要翻译： 根据本发明，提供了用于干扰由乳头瘤病毒感染和/或转化的细胞的增殖的方法和组合物。 本发明的方法和组合物可用于治疗包括人在内的任何哺乳动物。 根据本发明，通过药学上可接受的施用E2肽模拟物治疗哺乳动物以减少特异性乳头瘤病毒相关疾病的症状，或防止其复发。
-
公开(公告)号：US4492329A
公开(公告)日：1985-01-08
申请号：US619364
申请日：1984-06-11
申请人： John Benson , Harold L. Hanel , Douglas A. Freeman
发明人： John Benson , Harold L. Hanel , Douglas A. Freeman
摘要： A tool for driving nails into hard surfaces wherein the driving power is provided by cartridges of explosive powder. An extrudible stop member is provided in the barrel of the tool in front of the piston which is impacted by the piston when the tool is overdriven. The stop member extrudes through a passage to the front of the barrel if repeated overdriving of the piston occurs thereby providing a visual indication of such condition existing. In addition, a novel clamping arrangement is disclosed for retaining the return dog for the piston in the barrel housing.
摘要翻译： 用于将钉子驱动到硬表面的工具，其中驱动力由爆炸性粉末的药筒提供。 在工具前部的活塞的筒体内设有可挤压的止动件，当工具过度驱动时，活塞受到活塞的冲击。 如果活塞的重复过度驱动发生，止动构件通过通道挤出到桶的前部，从而提供存在这种状况的视觉指示。 此外，公开了一种新颖的夹紧装置，用于将活塞的返回爪保持在枪管壳体中。
-
公开(公告)号：US20160353729A1
公开(公告)日：2016-12-08
申请号：US14731714
申请日：2015-06-05
申请人： John Benson , Nereida Benson
发明人： John Benson , Nereida Benson
CPC分类号： A01M21/043
摘要： A fluid dispensing assembly for discretely applying an herbicide to a plant includes a dispenser that may selectively release a fluid. The dispenser may be positioned proximate a plant such that the fluid is dispensed onto the plant. A container is removably coupled to the dispenser. The container contains a fluid such that the dispenser selectively releases the fluid.
摘要翻译： 用于将除草剂离散施用于植物的流体分配组件包括可以选择性地释放流体的分配器。 分配器可以位于植物附近，使得流体被分配到植物上。 容器可拆卸地联接到分配器。 容器包含流体，使得分配器选择性地释放流体。
-
10.发明授权公开(公告)号：US09468421B2
公开(公告)日：2016-10-18
申请号：US13533660
申请日：2012-06-26
申请人： John Benson , Liexiang Fan
发明人： John Benson , Liexiang Fan
CPC分类号： A61B8/5223 , A61B8/461 , A61B8/463 , A61B8/485
摘要： Information associated with shear calculation is also displayed in ultrasound shear wave imaging. More information than just a shear wave image is provided for diagnosis. Information about the quality or variables used to determine shear is also displayed. This additional information may assist the user in determining whether the shear information indicates tissue characteristics or unreliable shear calculation.
摘要翻译： 与剪切计算相关的信息也显示在超声剪切波成像中。 提供的信息不仅仅是剪切波图像用于诊断。 还显示有关用于确定剪切的质量或变量的信息。 该附加信息可以帮助用户确定剪切信息是指示组织特征还是不可靠的剪切计算。
-
-
-
-
-
-
-
-
-
搜索结果
37 条记录 (耗时 0.038 秒)