发明申请
US20090247770A1 PROCESS FOR MAKING LACTAM TACHYKININ RECEPTOR ANTAGONISTS
审中-公开
制备LACTAM TACHYKININ受体拮抗剂的方法
- 专利标题： PROCESS FOR MAKING LACTAM TACHYKININ RECEPTOR ANTAGONISTS
- 专利标题（中）： 制备LACTAM TACHYKININ受体拮抗剂的方法
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申请号： US12309999申请日： 2007-08-03
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公开(公告)号： US20090247770A1公开(公告)日： 2009-10-01
- 发明人: Kevin R. Campos , Cheng Chen , Hideaki Ishibashi , Shinji Kato , Artis Klapars , Yoshinori Kohmura , David J. Pollard , Akihiro Takezawa , Jacob H. Waldman , Debra Wallace , Nobuyoshi Yasuda
- 申请人： Kevin R. Campos , Cheng Chen , Hideaki Ishibashi , Shinji Kato , Artis Klapars , Yoshinori Kohmura , David J. Pollard , Akihiro Takezawa , Jacob H. Waldman , Debra Wallace , Nobuyoshi Yasuda
- 国际申请： PCT/US2007/017406 WO 20070803
- 主分类号： C07D207/24
- IPC分类号： C07D207/24
摘要：
The present invention is directed to a process for preparing α,α disubstituted γ-lactam derivatives of formula (I) that are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The compounds are useful in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
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