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    Process for preparing amino compounds by using salen-manganese complexes as the catalyst
    4.
    发明授权
    Process for preparing amino compounds by using salen-manganese complexes as the catalyst 失效
    以salen-Mn络合物为催化剂制备氨基化合物的方法

    公开(公告)号：US06723879B2

    公开(公告)日：2004-04-20

    申请号：US10275634

    申请日：2002-11-07

    申请人： Tsutomu Katsuki ,  Yoshinori Kohmura

    发明人： Tsutomu Katsuki ,  Yoshinori Kohmura

    IPC分类号： C07C30340

    CPC分类号： B01J31/2243 ,  B01J31/0222 ,  B01J31/0232 ,  B01J31/0237 ,  B01J31/0271 ,  B01J31/1805 ,  B01J2231/46 ,  B01J2531/0252 ,  B01J2531/72 ,  C07C303/40 ,  C07C311/20

    摘要： Disclosed is a process for the enantioselective production of an optically active amino compound by the amination of the C—H bond of an organic compound. The amino compound is produced by converting the C—H bond at the allyl position of an alkene or the C—H bond at the benzyl position of an alkylarene to the corresponding C—N bond, using a salen-manganese complex as the catalyst and N-substituted iminoaryliodinane as the amination agent. Both the catalytic activity and the enantioselectivity are very high when there is used a catalyst in which the 3- and 5-positions of the salicylaldehyde moiety of the salen ligand are substituted with an electron-withdrawing group, particularly with a halogen atom.

    摘要翻译： 公开了通过胺化有机化合物的C-H键来对映选择性地制备光学活性氨基化合物的方法。 氨基化合物是通过将烯烃烯丙基位置的CH键或烷基芳烃的苄基位置处的CH键转化为相应的CN键，使用salen-锰络合物作为催化剂，将N-取代的亚氨基芳基碘烷作为 胺化剂。 当使用其中salen配体的水杨醛部分的3位和5位被吸电子基团，特别是卤素原子取代的催化剂时，催化活性和对映体选择性都非常高。