发明申请
US20090253133A1 ENHANCED T CELL RECEPTOR-MEDIATED TUMOR NECROSIS FACTOR SUPERFAMILY AND CHEMOKINE MRNA EXPRESSION IN PERIPHERAL BLOOD LEUKOCYTES IN PATIENTS WITH CROHN'S DISEASE
有权
增强T细胞受体介导的肿瘤坏死因子超家族和CHEMOKINE在外周血白细胞介素的表达与患有慢性疾病的患者
- 专利标题： ENHANCED T CELL RECEPTOR-MEDIATED TUMOR NECROSIS FACTOR SUPERFAMILY AND CHEMOKINE MRNA EXPRESSION IN PERIPHERAL BLOOD LEUKOCYTES IN PATIENTS WITH CROHN'S DISEASE
- 专利标题（中）： 增强T细胞受体介导的肿瘤坏死因子超家族和CHEMOKINE在外周血白细胞介素的表达与患有慢性疾病的患者
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申请号： US12296425申请日： 2007-04-05
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公开(公告)号： US20090253133A1公开(公告)日： 2009-10-08
- 发明人: Masato Mitsuhashi , Stephan R. Targan
- 申请人： Masato Mitsuhashi , Stephan R. Targan
- 申请人地址： JP TOKYO US CA IRVINE US CA LOS ANGELES
- 专利权人： HITACHI CHEMICAL CO., LTD,HITACHI CHEMICAL RESEARCH CENTER, INC,CEDARS-SINAI MEDICAL CENTER
- 当前专利权人： HITACHI CHEMICAL CO., LTD,HITACHI CHEMICAL RESEARCH CENTER, INC,CEDARS-SINAI MEDICAL CENTER
- 当前专利权人地址： JP TOKYO US CA IRVINE US CA LOS ANGELES
- 国际申请： PCT/US07/08597 WO 20070405
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68
摘要：
A method is disclosed for determining whether a human having Crohn's disease is likely to respond to a therapy targeting a TNFSF member or a cytokine by measuring the level of certain mRNAs in response to a stimulus. A method of evaluating the effectiveness of a Crohn's disease therapy in a human is also disclosed. Furthermore, a method of screening compounds for use in the treatment of Crohn's disease is disclosed. A method of monitoring the disease state over time in Crohn's disease patients is also disclosed.
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