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公开(公告)号：US09290543B2
公开(公告)日：2016-03-22
申请号：US12036588
申请日：2008-02-25
发明人： Robert M. Hershberg , Nancy Ann Hosken , Michael J. Lodes , Raodoh Mohamath , Stephan R. Targan
IPC分类号： G01N33/50 , C07K14/195 , C07K14/205 , A61K38/00 , A61K39/00 , C07K14/00 , G01N33/68
CPC分类号： C07K16/1232 , A61K38/00 , A61K39/00 , A61K39/40 , A61K45/06 , A61K2039/505 , A61K2039/523 , A61K2039/53 , C07K14/001 , C07K14/195 , C07K14/205 , C07K2317/21 , C07K2317/24 , C07K2317/76 , C07K2319/00 , G01N33/505 , G01N33/6893 , G01N2800/065
摘要： Compositions and methods for the therapy and diagnosis of Inflammatory Bowel Disease (IBD), including Crohn's Disease and Ulcerative Colitis, are disclosed. Illustrative compositions comprise one or more bacterial polypeptides, immunogenic portions thereof, polynucleotides that encode such polypeptides, antigen presenting cell that expresses such polypeptides, and T cells that are specific for cells expressing such polypeptides. The disclosed compositions are useful, for example, in the diagnosis, prevention and/or treatment of IBD.
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2.发明申请公开(公告)号：US20130012602A1
公开(公告)日：2013-01-10
申请号：US13521199
申请日：2011-01-13
IPC分类号： C12Q1/68 , G01N27/447 , A61P1/00 , C40B30/04 , A61K35/00
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present invention relates to prognosing, diagnosing and treating of Crohn's disease. The invention also provides prognosis, diagnosis, and treatment that are based upon the presence of one or more genetic risk factors at the ZNF365 genetic locus
摘要翻译： 本发明涉及克罗恩病的预后，诊断和治疗。 本发明还提供了基于在ZNF365遗传基因座上存在一种或多种遗传危险因素的预后，诊断和治疗
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3.发明申请METHODS OF ASSESSING CROHN'S DISEASE PATIENT PHENOTYPE BY I2, OMPC AND ASCA SEROLOGIC RESPONSE 审中-公开通过I2，OMPC和ASCA行为反应来评估冠心病患者的方法公开(公告)号：US20120208212A1
公开(公告)日：2012-08-16
申请号：US13312960
申请日：2011-12-06
申请人： Stephan R. Targan , Eric A. Vasiliauskas , William S. Mow , Huiying Yang , Phillip R. Fleshner , Jerome I. Rotter
发明人： Stephan R. Targan , Eric A. Vasiliauskas , William S. Mow , Huiying Yang , Phillip R. Fleshner , Jerome I. Rotter
IPC分类号： G01N33/566
CPC分类号： G01N33/686 , C12Q1/6883 , C12Q2600/156 , G01N33/6893 , G01N2469/20 , G01N2800/065
摘要： The invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease in a subject having Crohn's disease by determining the presence or absence of IgA anti-I2 antibodies in the subject, where the presence of the IgA anti-I2 antibodies indicates that the subject has a clinical subtype of Crohn's disease. In one embodiment, a method of the invention is practiced by further determining the presence or absence in the subject of a NOD2 variant, anti-Saccharomyces cerevisiae antibodies (ASCA), IgA anti-OmpC antibodies, or perinuclear anti-neutrophil cytoplasmic antibodies (pANCA). The methods of the invention can be used to diagnose or predict susceptibility to a clinical subtype of Crohn's disease, for example, a fibrostenotic subtype, a subtype characterized by the need for small bowel surgery, or a subtype characterized by the absence of features of ulcerative colitis.
摘要翻译： 本发明提供一种诊断或预测克罗恩病临床亚型易感性的方法，其通过测定受试者中IgA抗-I2抗体的存在或不存在，其中IgA抗-I2抗体的存在表明 该受试者具有克罗恩病的临床亚型。 在一个实施方案中，通过进一步确定受试者中NOD2变体，抗酿酒酵母抗体（ASCA），IgA抗OmpC抗体或核周抗中性粒细胞胞质抗体（pANCA）的存在或不存在来实施本发明的方法 ）。 本发明的方法可以用于诊断或预测对克罗恩病的临床亚型的易感性，例如纤维狭窄亚型，特征在于需要小肠手术的亚型或特征在于不存在溃疡特征的亚型 结肠炎。
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4.发明授权Characterization of the CBir1 antigenic response for diagnosis and treatment of Crohn's disease 有权用于诊断和治疗克罗恩病的CBir1抗原应答的表征公开(公告)号：US08153443B2
公开(公告)日：2012-04-10
申请号：US12599549
申请日：2008-05-09
IPC分类号： G01N33/564 , C12Q1/68 , A01N61/00 , A61K31/00
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , C12Q2600/172
摘要： This invention provides methods of diagnosing or predicting susceptibility to Crohn's Disease by determining the presence or absence of genetic variants. In one embodiment, the present invention provides methods to diagnose and/or predict susceptibility to Crohn's Disease in an individual by determining the presence or absence of anti-Cbir1 reactivity and the presence or absence of TLR5 risk variants. In another embodiment, the present invention provides methods to diagnose Crohn's Disease by determining the presence or absence of NFKB1 haplotype H3 and/or ASCA expression. In another embodiment, the present invention provides methods of diagnosing Crohn's Disease by determining the presence or absence of Cbir1 specific peripheral blood T cell proliferation.
摘要翻译： 本发明通过确定遗传变异体的存在或不存在来提供诊断或预测克罗恩病敏感性的方法。 在一个实施方案中，本发明提供了通过确定抗Cbir1反应性的存在或不存在以及是否存在TLR5风险变体来诊断和/或预测个体中克罗恩病易感性的方法。 在另一个实施方案中，本发明通过确定NFκB1单倍型H3和/或ASCA表达的存在或不存在来提供诊断克罗恩病的方法。 在另一个实施方案中，本发明通过确定Cbir1特异性外周血T细胞增殖的存在或不存在来提供诊断克罗恩病的方法。
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5.发明授权Diagnosis, prevention and treatment of Crohn's disease using the OmpC antigen 有权使用OmpC抗原诊断，预防和治疗克罗恩病公开(公告)号：US07993865B2
公开(公告)日：2011-08-09
申请号：US11561024
申请日：2006-11-17
IPC分类号： G01N33/564 , G01N33/569
CPC分类号： G01N33/56972 , G01N33/6854 , G01N2333/195 , G01N2333/245 , G01N2333/395 , G01N2469/20 , Y10S435/849 , Y10S435/965 , Y10S435/973 , Y10S436/811
摘要： The present invention provides a method of diagnosing Crohn's disease in a subject by determining the presence or absence or IgA anti-OmpC antibodies in the subject, where the presence of the IgA anti-OmpC antibodies indicates that the subject has Crohn's disease.
摘要翻译： 本发明提供了一种通过测定受试者中存在或不存在或IgA抗OmpC抗体来诊断受试者中的克罗恩病的方法，其中IgA抗OmpC抗体的存在表明受试者患有克罗恩氏病。
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6.发明申请CHARACTERIZATION OF THE CBIR1 ANTIGENIC RESPONSE FOR DIAGNOSIS AND TREATMENT OF CROHN'S DISEASE 有权CBIR1抗原反应诊断和治疗高血糖病的特征公开(公告)号：US20100284999A1
公开(公告)日：2010-11-11
申请号：US12599549
申请日：2008-05-09
IPC分类号： A61K39/395 , C12Q1/68 , C12Q1/02 , A61P1/00
CPC分类号： C12Q1/6883 , C12Q2600/112 , C12Q2600/156 , C12Q2600/172
摘要： This invention provides methods of diagnosing or predicting susceptibility to Crohn's Disease by determining the presence or absence of genetic variants. In one embodiment, the present invention provides methods to diagnose and/or predict susceptibility to Crohn's Disease in an individual by determining the presence or absence of anti-Cbir1 reactivity and the presence or absence of TLR5 risk variants. In another embodiment, the present invention provides methods to diagnose Crohn's Disease by determining the presence or absence of NFKB1 haplotype H3 and/or ASCA expression. In another embodiment, the present invention provides methods of diagnosing Crohn's Disease by determining the presence or absence of Cbir1 specific peripheral blood T cell proliferation.
摘要翻译： 本发明通过确定遗传变异体的存在或不存在来提供诊断或预测克罗恩病敏感性的方法。 在一个实施方案中，本发明提供了通过确定抗Cbir1反应性的存在或不存在以及是否存在TLR5风险变体来诊断和/或预测个体中克罗恩病易感性的方法。 在另一个实施方案中，本发明通过确定NFκB1单倍型H3和/或ASCA表达的存在或不存在来提供诊断克罗恩病的方法。 在另一个实施方案中，本发明通过确定Cbir1特异性外周血T细胞增殖的存在或不存在来提供诊断克罗恩病的方法。
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7.发明申请METHODS OF USING GENETIC VARIANTS TO DIAGNOSE AND PREDICT INFLAMMATORY BOWEL DISEASE 审中-公开使用遗传变异体进行诊断和预防炎症性皮肤疾病的方法公开(公告)号：US20100240043A1
公开(公告)日：2010-09-23
申请号：US12675718
申请日：2008-10-20
申请人： Jerome I. Rotter , Kent D. Taylor , Stephan R. Targan , Dermot P. McGovern , Ling Mei , Xiaowen Su
发明人： Jerome I. Rotter , Kent D. Taylor , Stephan R. Targan , Dermot P. McGovern , Ling Mei , Xiaowen Su
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present invention relates to methods of diagnosing susceptibility to Inflammatory Bowel Disease and subtypes of Inflammatory Bowel Disease. In one embodiment, the present invention provides a method of diagnosing susceptibility to Inflammatory Bowel Disease by determining the presence of one or more risk variants at the DR3 locus, GATA3 locus, SIN(EFS) locus, BTLA locus, LIGHT locus and MAGE locus.
摘要翻译： 本发明涉及诊断易感性肠炎和炎症性肠病亚型的易感性的方法。 在一个实施方案中，本发明提供了通过确定在DR3基因座，GATA3基因座，SIN（EFS）基因座，BTLA基因座，LIGHT基因座和MAGE基因座处存在一种或多种风险变体来诊断易感性肠炎易感性的方法。
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公开(公告)号：US6008335A
公开(公告)日：1999-12-28
申请号：US933824
申请日：1997-09-19
IPC分类号： C07K14/705 , C07K16/28 , C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C07K16/2821 , C07K14/70525 , C12Q1/6883 , C12Q2600/156
摘要： A novel association between IBD and a polymorphism at amino acid residue 241 of ICAM-1 has been discovered. In accordance with the present invention there is provided methods of screening for IBD, methods for treating IBD, antibodies specifically reactive with ICAM-1 encoded by R241 allele and kits which exploit the inventive methods.
摘要翻译： 已经发现了IBD与ICAM-1氨基酸残基241之间的多态性的新型关联。 根据本发明，提供了筛选IBD的方法，用于治疗IBD的方法，与由R241等位基因编码的ICAM-1特异性反应的抗体以及利用本发明方法的试剂盒。
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公开(公告)号：US6001569A
公开(公告)日：1999-12-14
申请号：US798668
申请日：1997-02-11
CPC分类号： C12Q1/6858 , C12Q1/6883 , C12Q2600/156 , C12Q2600/172
摘要： A novel association between certain tumor necrosis factor microsatellite alleles and Crohn's disease has been discovered. In accordance with the present invention, there is provided methods for screening for Crohn's disease comprising detecting the presence or absence of nucleic acid of a subject encoding TNF microsatellite alleles associated with Crohn's disease, wherein the presence of nucleic acid encoding three or more of the alleles is indicative of Crohn's disease. Kits useful for screening for Crohn's disease are also provided which comprise nucleic acid encoding TNF microsatellite alleles associated with Crohn's disease.
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10.发明授权Method of diagnosing a clinical subtype of crohn's disease with features of ulcerative colitis 失效诊断具有溃疡性结肠炎特征的克罗恩病的临床亚型的方法
公开(公告)号：US5916748A
公开(公告)日：1999-06-29
申请号：US689873
申请日：1996-08-15
IPC分类号： C12Q1/68 , G01N33/569 , G01N33/68 , G01N33/564
CPC分类号： G01N33/6893 , C12Q1/6883 , G01N33/56972 , C12Q2600/112 , C12Q2600/156 , G01N2800/065
摘要： The present invention provides a method of diagnosing a clinical subtype of Crohn's disease (CD) by determining whether perinuclear anti-neutrophil antibodies (pANCA) are present in a patient with CD, where the presence of pANCA indicates the clinical subtype of CD with features of ulcerative colitis (UC). The invention also provides a method of diagnosing a clinical subtype of CD by detecting an Arg.sup.241 allele at an ICAM-1 locus in a patient with CD, where the Arg.sup.241 allele indicates a clinical subtype of CD with features of ulcerative colitis. In addition, the invention provides a method of diagnosing a pANCA-positive subtype of CD by detecting an Arg.sup.241 allele at an ICAM-1 locus in a patient with CD, where the Arg.sup.241 allele indicates the pANCA-positive subtype of CD.
摘要翻译： 本发明提供了一种诊断克罗恩氏病（CD）的临床亚型的方法，该方法是通过确定是否存在CD患者中的核周抗中性粒细胞抗体（pANCA），其中pANCA的存在表示CD的临床亚型， 溃疡性结肠炎（UC）。 本发明还提供了通过检测患有CD的患者的ICAM-1位点处的Arg241等位基因来诊断CD的临床亚型的方法，其中Arg241等位基因表示具有溃疡性结肠炎特征的CD的临床亚型。 另外，本发明提供了通过检测患有CD的患者中ICAM-1位点处的Arg241等位基因来诊断CD的pANCA阳性亚型的方法，其中Arg241等位基因指示CD的pANCA阳性亚型。
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