发明申请
US20090270391A1 THIENOPYRIDINE DERIVATIVE, OR QUINOLINE DERIVATIVE, OR QUINAZOLINE DERIVATIVE, HAVING c-MET AUTOPHOSPHORYLATION INHIBITING POTENCY
审中-公开
三烯衍生物衍生物或喹啉衍生物或喹唑啉衍生物，具有c-MET自动抑制抑制作用
- 专利标题： THIENOPYRIDINE DERIVATIVE, OR QUINOLINE DERIVATIVE, OR QUINAZOLINE DERIVATIVE, HAVING c-MET AUTOPHOSPHORYLATION INHIBITING POTENCY
- 专利标题（中）： 三烯衍生物衍生物或喹啉衍生物或喹唑啉衍生物，具有c-MET自动抑制抑制作用
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申请号： US11910078申请日： 2006-03-28
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公开(公告)号： US20090270391A1公开(公告)日： 2009-10-29
- 发明人: Kazuo Kubo , Takayuki Furuta , Tatsushi Osawa , Atsushi Miwa
- 申请人： Kazuo Kubo , Takayuki Furuta , Tatsushi Osawa , Atsushi Miwa
- 申请人地址： JP Shibuya-ku, Tokyo
- 专利权人： Kirin Pharma Kabushiki Kaisha
- 当前专利权人： Kirin Pharma Kabushiki Kaisha
- 当前专利权人地址： JP Shibuya-ku, Tokyo
- 优先权： JP2005-092881 20050328
- 国际申请： PCT/JP2006/306334 WO 20060328
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; C07D495/04 ; A61K31/4365 ; A61K31/4709 ; C07D401/12 ; C07D413/12 ; A61P35/00
摘要：
An objective of the present invention is to provide compounds having antitumor activity. According to the present invention, there is provided compounds represented by formula (I) and pharmaceutically acceptable salts thereof, and solvates thereof: wherein R1 represents H or a substitutable unsaturated five- or six-membered heterocyclic ring; R2 represents H; X represents CH or N; Z represents O or S; E is absent or represents halogen, alkyl, or alkoxy; J represents S or O; and T represents phenyl, an unsaturated five- or six-membered heterocyclic ring, an unsaturated nine- or ten-membered bicyclic carbocyclic ring or heterocyclic ring.
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