发明申请
- 专利标题： LONG LASTING NATRIURETIC PEPTIDE DERIVATIVES
- 专利标题（中）： 长激活肽肽衍生物
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申请号： US12253856申请日： 2008-10-17
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公开(公告)号： US20090275506A1公开(公告)日： 2009-11-05
- 发明人: Peter BAKIS , Dominique P. Bridon , Julie Carette , France LeClaire , Roger Leger , Martin Robitaille
- 申请人： Peter BAKIS , Dominique P. Bridon , Julie Carette , France LeClaire , Roger Leger , Martin Robitaille
- 申请人地址： CA Montreal
- 专利权人： Conjuchem Biotechnologies, Inc.
- 当前专利权人： Conjuchem Biotechnologies, Inc.
- 当前专利权人地址： CA Montreal
- 主分类号： A61K38/16
- IPC分类号： A61K38/16 ; C07K14/00 ; C07K1/00
摘要：
This invention relates to long lasting natriuretic peptide (NP) derivatives. The NP derivative has a NP peptide and a reactive entity coupled to the NP peptide. The reactive entity is able to covalently bond with a functionality on a blood component. In particular, this invention relates to NP derivatives having an extended in vivo half-life, and method for the treatment of cardiovascular diseases and disorders such as acute decompensated congestive heart failure (CHF) and chronic CHF.
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