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1.发明申请公开(公告)号：US20100000686A1
公开(公告)日：2010-01-07
申请号：US12166947
申请日：2008-07-02
Applicant: Martin Robitaille , Steve Gagnon
Inventor： Martin Robitaille , Steve Gagnon
CPC classification number: B65H59/04 , B65H2701/37 , B65H2701/375
Abstract: The present invention discloses a roll holder for tape dispenser and a tape dispenser assembly therewith. The roll holder comprises a cylindrical body and an annular portion made from a material having a high friction coefficient, the annular portion being fixed inside the cylindrical body. The roll holder tape dispenser is supported by a shaft. Two cylindrical bodies are connected to a roll of tape, one at each extremity of the tape spool by press-fitting. The shaft passes through the annular portion and the friction occurring between the shaft and annular portion induce a tension in the tape when the tape is unwound from the roll.
Abstract translation: 本发明公开了一种用于胶带分配器的卷筒保持器和一个带分配器组件。 辊保持器包括圆筒体和由具有高摩擦系数的材料制成的环形部分，环形部分固定在圆柱体内。 卷筒胶带分配器由轴支撑。 两个圆柱体连接到一卷胶带，一个通过压配合在带卷轴的每个末端。 轴通过环形部分，并且当带从卷上展开时，在轴和环形部分之间产生的摩擦引起带中的张力。
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2.发明授权Long-lasting antiviral fusion inhibitor peptide conjugates comprising albumin and human immunodeficiency virus (HIV) peptides 失效包含白蛋白和人类免疫缺陷病毒（HIV）肽的长效抗病毒融合抑制剂肽缀合物公开(公告)号：US07582301B1
公开(公告)日：2009-09-01
申请号：US09623533
申请日：2000-05-17
Applicant: Dominique P. Bridon , Robert P. Dufresne , Nissab Boudjellab , Martin Robitaille , Peter G. Milner
Inventor： Dominique P. Bridon , Robert P. Dufresne , Nissab Boudjellab , Martin Robitaille , Peter G. Milner
IPC: A61K39/385 , A61K39/21
CPC classification number: C07K14/005 , A61K38/00 , C12N2740/16122
Abstract: Peptides exhibiting anti-viral and anti-fusogenic activity are modified to provide greater stability and improved half-life in vivo. The selected peptides include fusion inhibitors DP178 and DP107 and related peptides and analogs thereof. The modified peptides are capable of forming covalent bonds with one or more blood components, preferably a mobile blood component.
Abstract translation: 展示抗病毒和抗融合活性的肽被修饰以提供更大的稳定性和改善的体内半衰期。 所选择的肽包括融合抑制剂DP178和DP107及其相关肽及其类似物。 修饰的肽能够与一种或多种血液成分，优选移动血液成分形成共价键。
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3.发明授权Long lasting glucagon-like peptide 2 (glp-2) for the treatment of gastrointestinal diseases and disorders 失效持久的胰高血糖素样肽2（glp-2）用于治疗胃肠道疾病和病症公开(公告)号：US07112567B2
公开(公告)日：2006-09-26
申请号：US10203808
申请日：2002-02-15
Applicant: Dominique P. Bridon , Nissab Boudjellab , Roger Léger , Martin Robitaille , Karen Thibaudeau , Julie Carette
Inventor： Dominique P. Bridon , Nissab Boudjellab , Roger Léger , Martin Robitaille , Karen Thibaudeau , Julie Carette
IPC: A61K38/00
CPC classification number: C07K14/605 , A61K38/26 , A61K38/38 , A61K47/643 , C07K2319/00 , A61K2300/00
Abstract: This invention relates to glucagon-like peptide 2 (GLP-2) derivatives. In particular this invention relates to GLP-2 peptide derivatives having an extended in vivo half-life, for the treatment or prevention of gastrointestinal disorders or diseases such as inflammatory bowel disease and other gastrointestinal functions, from any segment of the gastrointestinal tract, from the oesophagus to the anus.
Abstract translation: 本发明涉及胰高血糖素样肽2（GLP-2）衍生物。 特别地，本发明涉及具有延长的体内半衰期的GLP-2肽衍生物，用于治疗或预防来自胃肠道的任何部分的胃肠道疾病或诸如炎性肠病和其它胃肠功能的疾病 食道到肛门。
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公开(公告)号：US07090851B1
公开(公告)日：2006-08-15
申请号：US09657336
申请日：2000-09-07
Applicant: Dominique P. Bridon , Robert R. Dufresne , Nissab Boudjellab , Martin Robitaille , Peter G. Milner
Inventor： Dominique P. Bridon , Robert R. Dufresne , Nissab Boudjellab , Martin Robitaille , Peter G. Milner
IPC: A61K39/385
CPC classification number: C07K14/005 , C12N2740/16122
Abstract: Peptides exhibiting anti-viral and anti-fusogenic activity are modified to provide greater stability and improved half-life in vivo. The selected peptides include fusion inhibitors DP178 and DP107 and related peptides and analogs thereof. The modified peptides are capable of forming covalent bonds with one or more blood components, preferably a mobile blood component.
Abstract translation: 展示抗病毒和抗融合活性的肽被修饰以提供更大的稳定性和改善的体内半衰期。 所选择的肽包括融合抑制剂DP178和DP107及其相关肽及其类似物。 修饰的肽能够与一种或多种血液成分，优选移动血液成分形成共价键。
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公开(公告)号：US20050176641A1
公开(公告)日：2005-08-11
申请号：US11040810
申请日：2005-01-21
Applicant: Peter Bakis , Dominique Bridon , Julie Carette , France Leclaire , Roger Leger , Martin Robitaille
Inventor： Peter Bakis , Dominique Bridon , Julie Carette , France Leclaire , Roger Leger , Martin Robitaille
CPC classification number: A61K38/2242 , A61K47/62
Abstract: This invention relates to long lasting natriuretic peptide (NP) derivatives. The NP derivative has a NP peptide and a reactive entity coupled to the NP peptide. The reactive entity is able to covalently bond with a functionality on a blood component. In particular, this invention relates to NP derivatives having an extended in vivo half-life, and method for the treatment of cardiovascular diseases and disorders such as acute decompensated congestive heart failure (CHF) and chronic CHF.
Abstract translation: 本发明涉及长效利钠肽（NP）衍生物。 NP衍生物具有NP肽和与NP肽偶联的反应性实体。 反应性实体能够与血液成分上的官能团共价键合。 特别地，本发明涉及具有延长的体内半衰期的NP衍生物，以及用于治疗心血管疾病和疾病如急性失代偿性充血性心力衰竭（CHF）和慢性CHF的方法。
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Patent Agency Ranking
公开(公告)号：US20050103916A1
公开(公告)日：2005-05-19
申请号：US10712883
申请日：2003-11-14
Applicant: Martin Robitaille , Steve Gagnon , Alain Carbonneau
Inventor： Martin Robitaille , Steve Gagnon , Alain Carbonneau
Abstract: An apparatus to prevent the tape from falling off the edge of the tape package when unwinding.
Abstract translation: 一种用于防止磁带在展开时从胶带包装边缘脱落的装置。
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公开(公告)号：US06706892B1
公开(公告)日：2004-03-16
申请号：US09656121
申请日：2000-09-06
Applicant: Alan M. Ezrin , Angelica Fleser , Martin Robitaille , Peter G. Milner , Dominique P. Bridon
Inventor： Alan M. Ezrin , Angelica Fleser , Martin Robitaille , Peter G. Milner , Dominique P. Bridon
IPC: A61K314015
CPC classification number: A61K9/0075 , A61K47/50 , A61K47/643
Abstract: Methods of and compositions for pulmonary delivery of therapeutic agents which are capable of forming covalent bonds with a site of interest or which have formed a covalent bond with a pulmonary solution protein are disclosed. Therapeutic agents useful in the invention include wound healing agents, antibiotics, anti-inflammatories, anti-oxidants, anti-proliferatives, immunosupressants, anti-infective and anti-cancer agents.
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公开(公告)号：US20110166061A1
公开(公告)日：2011-07-07
申请号：US12767646
申请日：2010-04-26
Applicant: John W. Erickson , Dominique P. Bridon , Martin Robitaille , Grant A. Krafft , Dong Xie , Elena Afonina , Jun Liang , Sandra De Meyer
Inventor： John W. Erickson , Dominique P. Bridon , Martin Robitaille , Grant A. Krafft , Dong Xie , Elena Afonina , Jun Liang , Sandra De Meyer
CPC classification number: C07K14/005 , A61K38/00 , C07K2319/00 , C12N2740/16122
Abstract: The present invention is concerned with This invention relates to C34 peptide derivatives that are inhibitors of viral infection and/or exhibit antifusogenic properties. In particular, this invention relates to C34 derivatives having inhibiting activity against human immunodeficiency virus (HIV), respiratory syncytial virus (RSV), human parainfluenza virus (HPV), measles virus (MeV), and simian immunodeficiency virus (SIV) with long duration of action for the treatment of the respective viral infections.
Abstract translation: 本发明涉及作为病毒感染抑制剂和/或表现出抗融合性质的C34肽衍生物。 特别地，本发明涉及具有长期持续时间的针对人免疫缺陷病毒（HIV），呼吸道合胞病毒（RSV），人副流感病毒（HPV），麻疹病毒（MeV）和猿猴免疫缺陷病毒（SIV））具有抑制活性的C34衍生物 的治疗各自病毒感染的作用。
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公开(公告)号：US07906482B2
公开(公告)日：2011-03-15
申请号：US11923222
申请日：2007-10-24
Applicant: Dominique P. Bridon , Roger Leger , Xicai Huang , Karen Thibaudeau , Martin Robitaille , Peter G. Milner
Inventor： Dominique P. Bridon , Roger Leger , Xicai Huang , Karen Thibaudeau , Martin Robitaille , Peter G. Milner
CPC classification number: C07K14/57545 , A61K38/00 , C07K19/00 , C07K2319/01
Abstract: The present invention relates to a compound comprising a PYY peptide or a functional derivative thereof, which is coupled to a reactive group. Such a reactive group is capable of reacting on a blood component so as to form a stable covalent bond therewith. The present invention also relates to a conjugate comprising such a compound which is covalently bonded to a blood component. Moreover, the invention also relates to a method of enhancing, in a patient, the anti-obesity activity of a PYY peptide or functional derivative thereof.
Abstract translation: 本发明涉及包含与反应性基团偶联的PYY肽或其功能性衍生物的化合物。 这样的反应性基团能够对血液成分进行反应，与其形成稳定的共价键。 本发明还涉及包含共价键合到血液成分上的化合物的缀合物。 此外，本发明还涉及在患者中增强PYY肽或其功能性衍生物的抗肥胖活性的方法。
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公开(公告)号：US20090275506A1
公开(公告)日：2009-11-05
申请号：US12253856
申请日：2008-10-17
Applicant: Peter BAKIS , Dominique P. Bridon , Julie Carette , France LeClaire , Roger Leger , Martin Robitaille
Inventor： Peter BAKIS , Dominique P. Bridon , Julie Carette , France LeClaire , Roger Leger , Martin Robitaille
CPC classification number: A61K38/2242 , A61K47/62
Abstract: This invention relates to long lasting natriuretic peptide (NP) derivatives. The NP derivative has a NP peptide and a reactive entity coupled to the NP peptide. The reactive entity is able to covalently bond with a functionality on a blood component. In particular, this invention relates to NP derivatives having an extended in vivo half-life, and method for the treatment of cardiovascular diseases and disorders such as acute decompensated congestive heart failure (CHF) and chronic CHF.
Abstract translation: 本发明涉及长效利钠肽（NP）衍生物。 NP衍生物具有NP肽和与NP肽偶联的反应性实体。 反应性实体能够与血液成分上的官能团共价键合。 特别地，本发明涉及具有延长的体内半衰期的NP衍生物，以及用于治疗心血管疾病和疾病如急性失代偿性充血性心力衰竭（CHF）和慢性CHF的方法。
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