发明申请
US20090275618A1 1, 5-DIPHENYL-3-BENZYLAMINO-1, 5-DIHYDROPYRROLIDIN-2-ONE AS CB1 RECEPTOR MODULATORS
失效
1,5-二苯基-3-苯甲酰胺-1,5-二羟基吡啶-2-酮作为CB1受体调节剂
- 专利标题： 1, 5-DIPHENYL-3-BENZYLAMINO-1, 5-DIHYDROPYRROLIDIN-2-ONE AS CB1 RECEPTOR MODULATORS
- 专利标题（中）： 1,5-二苯基-3-苯甲酰胺-1,5-二羟基吡啶-2-酮作为CB1受体调节剂
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申请号： US12441570申请日： 2007-10-22
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公开(公告)号： US20090275618A1公开(公告)日： 2009-11-05
- 发明人: David Scott Coffey , Jingdan Hu , Stacy Jo Keding , Joseph Herman Krushinski, JR. , John Mehnert Schaus , David Edward Tupper
- 申请人： David Scott Coffey , Jingdan Hu , Stacy Jo Keding , Joseph Herman Krushinski, JR. , John Mehnert Schaus , David Edward Tupper
- 国际申请： PCT/US07/82042 WO 20071022
- 主分类号： A61K31/4439
- IPC分类号： A61K31/4439 ; C07D401/12 ; A61P25/18 ; A61P25/30 ; A61P3/04 ; A61P25/28
摘要：
Compounds and pharmaceutical compositions of Formula (I) by blockade of the CB1 receptors via an inverse agonism mechanism which are useful for reducing body weight in mammals, cognitive impairment associated with schizophrenia, mitigating treatment emergent weight gain observed during treatment with antipsychotics and have increased bioavailability.
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