发明申请
US20090281062A1 NOVEL NITROSO COMPOUNDS AS NITROXYL DONORS AND METHODS OF USE THEREOF
有权
新型硝基化合物作为硝基衍生物及其使用方法
- 专利标题： NOVEL NITROSO COMPOUNDS AS NITROXYL DONORS AND METHODS OF USE THEREOF
- 专利标题（中）： 新型硝基化合物作为硝基衍生物及其使用方法
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申请号： US12437512申请日： 2009-05-07
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公开(公告)号： US20090281062A1公开(公告)日： 2009-11-12
- 发明人: Lisa M. Frost , Stephen M. Courtney , Frederick A. Brookfield , Vincent J. Kalish
- 申请人： Lisa M. Frost , Stephen M. Courtney , Frederick A. Brookfield , Vincent J. Kalish
- 主分类号： A61K31/45
- IPC分类号： A61K31/45 ; C07D211/58 ; C07C205/01 ; C07D309/10 ; C07D405/12 ; A61K31/35 ; A61K31/225 ; A61K31/661 ; A61K31/4433 ; A61K31/444 ; A61P9/00 ; A61P35/00
摘要：
The invention relates to nitroso derivatives including carboxylic acid and phosphoric acid esters of hydroxy nitroso compounds that donate nitroxyl (HNO) under physiological conditions. The compounds and compositions of the invention are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure, ischemia/reperfusion injury and cancer.
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