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1.发明申请TRANSGLUTAMINASE TG2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF 审中-公开转谷氨酰胺酶TG2抑制剂，药物组合物及其使用方法公开(公告)号：US20150232420A1
公开(公告)日：2015-08-20
申请号：US14429288
申请日：2013-09-19
申请人： Celia DOMINGUEZ , Michael PRIME , Richard MARSTON , Frederick A. BROOKFIELD , Stephen M. COURTNEY , Douglas MACDONALD , John WITYAK , Christopher John YARNOLD , Darshan VAIDYA
发明人： Celia Dominguez , Michael Prime , Richard Marston , Frederick A. Brookfield , Stephen M. Courtney , Douglas Macdonald , John Wityak , Christopher John Yarnold , Darshan Vaidya
IPC分类号： C07C271/22 , C07D207/06 , C07D213/74 , C07D205/04 , C07D211/08 , C07D295/185 , C07D223/04
CPC分类号： C07C271/22 , C07D205/04 , C07D207/06 , C07D207/16 , C07D211/08 , C07D211/16 , C07D213/72 , C07D213/74 , C07D223/04 , C07D277/42 , C07D295/18 , C07D295/185 , C07D309/08 , C07D401/12
摘要： Certain compounds and pharmaceutically acceptable salts are provided herein. Also provided are pharmaceutical compositions comprising at least one compound or pharmaceutically acceptable salt therein and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain disease states responsive to the inhibition of transglutaminase TG2 activity are described. These disease states include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one compound or pharmaceutically acceptable salt thereof as a single active agent or administering at least one compound or pharmaceutically acceptable salt thereof in combination with one or more other therapeutic agents.
摘要翻译： 本文提供了某些化合物和药学上可接受的盐。 还提供了包含至少一种化合物或其药学上可接受的盐的药物组合物和一种或多种药学上可接受的载体。 描述了治疗患有某种疾病状态的患者对抑制转谷氨酰胺酶TG2活性有反应的方法。 这些疾病状态包括神经变性疾病如亨廷顿病。 还描述了治疗方法，包括给予至少一种化合物或其药学上可接受的盐作为单一活性剂，或者与一种或多种其它治疗剂组合施用至少一种化合物或其药学上可接受的盐。
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公开(公告)号：US08318705B2
公开(公告)日：2012-11-27
申请号：US12437512
申请日：2009-05-07
CPC分类号： C07C207/00 , C07C207/04 , C07C255/19 , C07D211/44 , C07D211/58 , C07D309/10 , C07D309/14 , C07D333/42 , C07D405/12 , C07D405/14 , C07D407/12 , C07D451/10 , C07F9/117 , C07F9/58 , C07F9/59
摘要： The invention relates to nitroso derivatives including carboxylic acid and phosphoric acid esters of hydroxy nitroso compounds that donate nitroxyl (HNO) under physiological conditions. The compounds and compositions of the invention are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure, ischemia/reperfusion injury and cancer.
摘要翻译： 本发明涉及在生理条件下给予硝酰基（HNO）的羟基亚硝基化合物的羧酸和磷酸酯的亚硝基衍生物。 本发明的化合物和组合物可用于治疗和/或预防对硝酰病毒治疗（包括心力衰竭，局部缺血/再灌注损伤和癌症）有反应的疾病或病症的发作和/或发展。
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3.发明申请公开(公告)号：US20090281062A1
公开(公告)日：2009-11-12
申请号：US12437512
申请日：2009-05-07
IPC分类号： A61K31/45 , C07D211/58 , C07C205/01 , C07D309/10 , C07D405/12 , A61K31/35 , A61K31/225 , A61K31/661 , A61K31/4433 , A61K31/444 , A61P9/00 , A61P35/00
CPC分类号： C07C207/00 , C07C207/04 , C07C255/19 , C07D211/44 , C07D211/58 , C07D309/10 , C07D309/14 , C07D333/42 , C07D405/12 , C07D405/14 , C07D407/12 , C07D451/10 , C07F9/117 , C07F9/58 , C07F9/59
摘要： The invention relates to nitroso derivatives including carboxylic acid and phosphoric acid esters of hydroxy nitroso compounds that donate nitroxyl (HNO) under physiological conditions. The compounds and compositions of the invention are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure, ischemia/reperfusion injury and cancer.
摘要翻译： 本发明涉及在生理条件下给予硝酰基（HNO）的羟基亚硝基化合物的羧酸和磷酸酯的亚硝基衍生物。 本发明的化合物和组合物可用于治疗和/或预防对硝酰病毒治疗（包括心力衰竭，局部缺血/再灌注损伤和癌症）有反应的疾病或病症的发作和/或发展。
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