发明申请
- 专利标题： Glycosylation Variants of BACE
- 专利标题（中）： BACE的糖基化变体
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申请号： US12341336申请日： 2008-12-22
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公开(公告)号： US20090286281A1公开(公告)日： 2009-11-19
- 发明人: John Anderson , Lisa McConlogue , Guriqbal Basi , Sukanto Sinha
- 申请人： John Anderson , Lisa McConlogue , Guriqbal Basi , Sukanto Sinha
- 专利权人： Elan Pharmaceuticals, Inc.
- 当前专利权人： Elan Pharmaceuticals, Inc.
- 主分类号： C12P21/02
- IPC分类号： C12P21/02 ; C07H21/00 ; C12N15/63 ; C12N5/10 ; C12N9/50
摘要：
Human BACE polypeptides having modifications to the N-linked glycosylation sites including one or more of the following amino acid substitutions: S174I, N223A, N153Q and N354S. DNA sequences, vectors, and host cells for producing the polypeptides. Crystalline protein compositions formed from the purified polypeptides. Methods of screening for compounds that inhibit Aβ using the polypeptides.
公开/授权文献
- US07718413B2 Glycosylation variants of BACE 公开/授权日：2010-05-18
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