发明申请
US20090298814A1 Novel salts of conjugated psychotropic drugs and processes of preparing same
审中-公开
联合精神药物的新型盐及其制备方法
- 专利标题: Novel salts of conjugated psychotropic drugs and processes of preparing same
- 专利标题(中): 联合精神药物的新型盐及其制备方法
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申请号: US11921578申请日: 2006-06-07
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公开(公告)号: US20090298814A1公开(公告)日: 2009-12-03
- 发明人: Abraham Nudelman , Ada Rephaeli , Irit Gil-Ad , Abraham Weizman , Shlomit Halachmi , Eran J. Benjamin
- 申请人: Abraham Nudelman , Ada Rephaeli , Irit Gil-Ad , Abraham Weizman , Shlomit Halachmi , Eran J. Benjamin
- 申请人地址: IL TEL-AVIV IL RAMAT-GAN IL JERUSALEM
- 专利权人: RAMOT AT TEL AVIV UNIVERISTY LTD,BAR-LLAN UNIVERSITY,BIOLINERX LTD
- 当前专利权人: RAMOT AT TEL AVIV UNIVERISTY LTD,BAR-LLAN UNIVERSITY,BIOLINERX LTD
- 当前专利权人地址: IL TEL-AVIV IL RAMAT-GAN IL JERUSALEM
- 国际申请: PCT/IL2006/000666 WO 20060607
- 主分类号: A61K31/5415
- IPC分类号: A61K31/5415 ; C07D417/06
摘要:
Novel chemical conjugates of a psychotropic drug residue and an amino-containing organic acid residue selected to reduce side effects induced by the psychotropic drug when administered per se, to enhance the therapeutic activity of the psychotropic drug and/or to exert anti-proliferative activity, in which the amino group is in the form of an acid addition salt thereof and which are characterized by high stability are disclosed. Further disclosed are processes for preparing the chemical conjugates and addition salts thereof, pharmaceutical compositions containing the chemical conjugates and methods utilizing the chemical conjugates for treating various medical conditions.
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