公开(公告)号：US20090298814A1

公开(公告)日：2009-12-03

申请号：US11921578

申请日：2006-06-07

申请人： Abraham Nudelman ,  Ada Rephaeli ,  Irit Gil-Ad ,  Abraham Weizman ,  Shlomit Halachmi ,  Eran J. Benjamin

发明人： Abraham Nudelman ,  Ada Rephaeli ,  Irit Gil-Ad ,  Abraham Weizman ,  Shlomit Halachmi ,  Eran J. Benjamin

IPC分类号： A61K31/5415 ,  C07D417/06

CPC分类号： C07D279/28 ,  A61K47/542

摘要： Novel chemical conjugates of a psychotropic drug residue and an amino-containing organic acid residue selected to reduce side effects induced by the psychotropic drug when administered per se, to enhance the therapeutic activity of the psychotropic drug and/or to exert anti-proliferative activity, in which the amino group is in the form of an acid addition salt thereof and which are characterized by high stability are disclosed. Further disclosed are processes for preparing the chemical conjugates and addition salts thereof, pharmaceutical compositions containing the chemical conjugates and methods utilizing the chemical conjugates for treating various medical conditions.

摘要翻译： 精神药物残基和含氨基的有机酸残基的新型化学共轭物被选择用于减少精神药物本身引起的副作用，以增强精神药物的治疗活性和/或发挥抗增殖活性， 其中氨基为其酸加成盐的形式，其特征在于高稳定性。 进一步公开的是制备化学共轭物及其加成盐的方法，含有化学共轭物的药物组合物和利用化学共轭物治疗各种医学病症的方法。