发明申请
US20090298871A1 SULFONYL-PHENYL-2H-[1,2,4]OXADIAZOL-5-ONE DERIVATIVES , PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS
有权
磺酰基-2H- [1,2,4]恶嗪-5-酮衍生物，其制备方法及其作为药物的用途
![SULFONYL-PHENYL-2H-[1,2,4]OXADIAZOL-5-ONE DERIVATIVES , PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS](/docs/US/2009-12-03/US20090298871A1/abs.jpg.600x600.jpg)
- 专利标题： SULFONYL-PHENYL-2H-[1,2,4]OXADIAZOL-5-ONE DERIVATIVES , PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS
- 专利标题（中）： 磺酰基-2H- [1,2,4]恶嗪-5-酮衍生物，其制备方法及其作为药物的用途
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申请号： US12480974申请日： 2009-06-09
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公开(公告)号： US20090298871A1公开(公告)日： 2009-12-03
- 发明人: Stefanie KEIL , Matthias URMANN , Karl SCHOENAFINGER , Wolfgang WENDLER , Maike GLIEN , Hans-Ludwig SCHAEFER , Eugen FALK
- 申请人： Stefanie KEIL , Matthias URMANN , Karl SCHOENAFINGER , Wolfgang WENDLER , Maike GLIEN , Hans-Ludwig SCHAEFER , Eugen FALK
- 申请人地址： FR Paris
- 专利权人： SANOFI-AVENTIS
- 当前专利权人： SANOFI-AVENTIS
- 当前专利权人地址： FR Paris
- 优先权： DE06025880.3 20061214; EP06025880.3 20061214
- 主分类号： A61K31/4725
- IPC分类号： A61K31/4725 ; C07D413/12 ; A61K31/4245
![SULFONYL-PHENYL-2H-[1,2,4]OXADIAZOL-5-ONE DERIVATIVES , PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS](/abs-image/US/2009/12/03/US20090298871A1/abs.jpg.150x150.jpg)
摘要：
The invention relates to sulfonyl-phenyl-oxadiazolones and to their physiologically acceptable salts and physiologically functional derivatives showing PPARdelta or PPARdelta and PPARgamma agonist activity.What are described are compounds of the formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparations. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistance is involved and demyelinating and other neurodegenerative disorders of the central and peripheral nervous system.
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