发明申请
- 专利标题： Impurities of Donepezil
- 专利标题（中）： 多奈哌齐的杂质
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申请号： US12301396申请日： 2007-05-18
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公开(公告)号： US20090298879A1公开(公告)日： 2009-12-03
- 发明人: Irena Krizmanic , Lidija Lerman , Zrinka Samardzic , Katarzyna Kaczorowska , Andrzej Manikowski , Barbara Zioro , Ivica Grebenar , Jasna Dogan Koruznjak
- 申请人： Irena Krizmanic , Lidija Lerman , Zrinka Samardzic , Katarzyna Kaczorowska , Andrzej Manikowski , Barbara Zioro , Ivica Grebenar , Jasna Dogan Koruznjak
- 申请人地址： HR Zagreb
- 专利权人： PLIVA Hrvatska d.o.o.
- 当前专利权人： PLIVA Hrvatska d.o.o.
- 当前专利权人地址： HR Zagreb
- 优先权： GB0609835.4 20060518
- 国际申请： PCT/GB2007/001872 WO 20070518
- 主分类号： A61K31/445
- IPC分类号： A61K31/445 ; C07C211/01 ; C07D211/06 ; A61P25/00 ; G01N30/02
摘要：
The present invention relates to impurities of donepezil, or a pharmaceutically acceptable salt thereof, which may be produced during synthesis and storage of donepezil, or a pharmaceutically-acceptable salt thereof, and to methods of identifying such impurities. The invention also relates to the use of these impurities in analytical techniques and to product that contain certain low levels of these impurities in particular the following impurities are disclosed: formula (I) and formula (II).