发明申请
- 专利标题： Glycosylation Engineering of Antibodies for Improving Antibody-Dependent Cellular Cytotoxicity
- 专利标题（中）： 用于改善抗体依赖性细胞毒性的抗体的糖基化工程
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申请号： US12409349申请日： 2009-03-23
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公开(公告)号： US20090304690A1公开(公告)日： 2009-12-10
- 发明人: PABLO UMANA , JOEL JEAN-MAIRET , JAMES E. BAILEY , Sean Bailey
- 申请人： PABLO UMANA , JOEL JEAN-MAIRET , JAMES E. BAILEY , Sean Bailey
- 申请人地址： CH SCHLIEREN-ZURICH
- 专利权人： GLYCART BIOTECHNOLOGY AG
- 当前专利权人： GLYCART BIOTECHNOLOGY AG
- 当前专利权人地址： CH SCHLIEREN-ZURICH
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C12P21/00 ; C12N5/06 ; C07K16/00
摘要：
The present invention relates to the field glycosylation engineering of proteins. More particular, the present invention is directed to the glycosylation engineering of proteins to provide proteins with improved therapeutic properties, e.g., antibodies, antibody fragments, or a fusion protein that includes a region equivalent to the Fc region of an immunoglobulin, with enhanced Fc-mediated cellular cytotoxicity.
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