发明申请
US20090311182A1 Macromolecular Delivery Systems for Non-Invasive Imaging, Evaluation and Treatment of Arthritis and Other Inflammatory Diseases
审中-公开
用于非侵入性成像，评估和治疗关节炎和其他炎症疾病的大分子递送系统
- 专利标题： Macromolecular Delivery Systems for Non-Invasive Imaging, Evaluation and Treatment of Arthritis and Other Inflammatory Diseases
- 专利标题（中）： 用于非侵入性成像，评估和治疗关节炎和其他炎症疾病的大分子递送系统
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申请号： US12351417申请日： 2009-01-09
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公开(公告)号： US20090311182A1公开(公告)日： 2009-12-17
- 发明人: Dong Wang , Xinming Liu , Ling-Dong Quan
- 申请人： Dong Wang , Xinming Liu , Ling-Dong Quan
- 主分类号： A61K31/573
- IPC分类号： A61K31/573 ; A61P29/00 ; A61K47/48 ; C07C243/10 ; C07K2/00 ; C08F20/58 ; A61K49/12
摘要：
This invention relates to biotechnology, more particularly, to water-soluble polymeric delivery systems for the imaging, evaluation and/or treatment of rheumatoid arthritis and other inflammatory diseases. Using modern MR imaging techniques, the specific accumulation of macromolecules in arthritic joints in adjuvant-induced arthritis in rats is demonstrated. The strong correlation between the uptake and retention of the MR contrast agent labeled polymer with histopathological features of inflammation and local tissue damage demonstrates the practical applications of the macromolecular delivery system of the invention.
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