公开(公告)号：US20090311182A1

公开(公告)日：2009-12-17

申请号：US12351417

申请日：2009-01-09

申请人： Dong Wang ,  Xinming Liu ,  Ling-Dong Quan

发明人： Dong Wang ,  Xinming Liu ,  Ling-Dong Quan

IPC分类号： A61K31/573 ,  A61P29/00 ,  A61K47/48 ,  C07C243/10 ,  C07K2/00 ,  C08F20/58 ,  A61K49/12

CPC分类号： A61K49/128 ,  A61K47/58 ,  A61K49/0002 ,  A61K49/0054

摘要： This invention relates to biotechnology, more particularly, to water-soluble polymeric delivery systems for the imaging, evaluation and/or treatment of rheumatoid arthritis and other inflammatory diseases. Using modern MR imaging techniques, the specific accumulation of macromolecules in arthritic joints in adjuvant-induced arthritis in rats is demonstrated. The strong correlation between the uptake and retention of the MR contrast agent labeled polymer with histopathological features of inflammation and local tissue damage demonstrates the practical applications of the macromolecular delivery system of the invention.

摘要翻译： 本发明涉及生物技术，更具体地涉及用于成像，评估和/或治疗类风湿性关节炎和其它炎性疾病的水溶性聚合物递送系统。 使用现代MR成像技术，证明了大鼠在佐剂诱导的关节炎中关节炎关节中大分子的特异性积累。 MR造影剂标记的聚合物的吸收和保留与炎症和局部组织损伤的组织病理特征之间的强相关性证明了本发明的大分子递送系统的实际应用。

公开(公告)号：USD1038035S1

公开(公告)日：2024-08-06

申请号：US29858338

申请日：2022-10-31

申请人： Xinming Liu

设计人： Xinming Liu

摘要： FIG. 1 is a front and top perspective view of a car charger, showing my new design;
FIG. 2 is a rear and bottom perspective view thereof;
FIG. 3 is a front elevation view thereof;
FIG. 4 is a rear elevation view thereof;
FIG. 5 is a left side elevation view thereof;
FIG. 6 is a right side elevation view thereof;
FIG. 7 is a top plan view thereof;
FIG. 8 is a bottom plan view thereof; and,
FIG. 9 is an enlarged perspective view of detail “9” identified in FIG. 8.
The dashed lines in the figures illustrate portions of the car charger that form no part of the claimed design. The dash dot dash lines in FIGS. 8 and 9 are for the purpose of illustrating the enlarged view indicators and form no part of the claimed design.