发明申请
US20090312344A1 ARYLPIPERAZINE DERIVATIVES AS ADRENERGIC RECEPTOR ANTAGONISTS
审中-公开
ARYLPIPERAZINE衍生物作为ADRENERGIC RECEPTOR ANTAGONISTS
- 专利标题： ARYLPIPERAZINE DERIVATIVES AS ADRENERGIC RECEPTOR ANTAGONISTS
- 专利标题（中）： ARYLPIPERAZINE衍生物作为ADRENERGIC RECEPTOR ANTAGONISTS
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申请号： US11569838申请日： 2005-05-31
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公开(公告)号： US20090312344A1公开(公告)日： 2009-12-17
- 发明人: Mohammad Salman , Somesh Sharma , Gyan Chand Yadav , Gobind Singh Kapkoti , Anurag Mishra , Praful Gupta , Nitya Anand , Anita Chugh , Kamna Nanda
- 申请人： Mohammad Salman , Somesh Sharma , Gyan Chand Yadav , Gobind Singh Kapkoti , Anurag Mishra , Praful Gupta , Nitya Anand , Anita Chugh , Kamna Nanda
- 优先权： IN992/DEL/2004 20040531
- 国际申请： PCT/IB05/01534 WO 20050531
- 主分类号： A61K31/496
- IPC分类号： A61K31/496 ; C07D403/02 ; A61P13/00 ; C07D241/04
摘要：
The present invention relates to α1, and/or α1d adrenergic receptor antagonists, which can function as α1a and/or α1d adrenergic receptor antagonist and can be used for the treatment of a disease or disorder mediated through α1a and/or an adrenergic receptor. Compounds disclosed herein can be used for the treatment of benign prostatic hyperplasia (BPH) and the related symptoms thereof. Further, compounds disclosed herein can be used for the treatment of lower urinary tract symptoms associated with or without BPH. Also provided are processes for preparing such compounds, pharmaceutical compositions thereof, and the methods of treating BPH or related symptoms thereof.
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