发明申请
- 专利标题: Screening Method
- 专利标题(中): 筛选方法
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申请号: US12225721申请日: 2007-03-29
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公开(公告)号: US20090317833A1公开(公告)日: 2009-12-24
- 发明人: Osamu Hazeki , Kaoru Hazeki , Masayuki Ii , Naoko Matsunaga
- 申请人: Osamu Hazeki , Kaoru Hazeki , Masayuki Ii , Naoko Matsunaga
- 优先权: JP2006-095936 20060330
- 国际申请: PCT/JP2007/056962 WO 20070329
- 主分类号: G01N33/53
- IPC分类号: G01N33/53
摘要:
The present invention provides a method of screening for a drug for the prophylaxis or treatment of at least one disease selected from the group consisting of cardiac disease, autoimmune disease, inflammatory disease, central nervous system disease, infectious disease, sepsis, severe sepsis and septic shock, which includes selecting a substance that binds to an intracellular region of TLR4, and inhibits signal transduction from said molecule, and a kit for this method, which contains (1) a cell that expresses wild-type TLR4 and (2) a cell that expresses a mutant TLR4, and which can detect a signal from TLR4 with expression of a reporter gene as an index.