发明申请
US20090318661A1 A BIOCOMPATIBLE, NON-BIODEGRADABLE, NON-TOXIC POLYMER USEFUL FOR NANOPARTICLE PHARMACEUTICAL COMPOSITIONS
有权
一种可生物降解，非生物降解的非毒性聚合物，用于纳米脂肪药物组合物
- 专利标题： A BIOCOMPATIBLE, NON-BIODEGRADABLE, NON-TOXIC POLYMER USEFUL FOR NANOPARTICLE PHARMACEUTICAL COMPOSITIONS
- 专利标题（中）： 一种可生物降解，非生物降解的非毒性聚合物，用于纳米脂肪药物组合物
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申请号： US12159310申请日： 2006-12-26
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公开(公告)号： US20090318661A1公开(公告)日： 2009-12-24
- 发明人: Anand C. Burman , Rama Mukherjee , Dhiraj Khattar , Sanjoy Mullick , Manu Jaggi , Manoj Kumar Singh , Mukesh Kumar , Deepak Prusthy , Pawan Kumar Gupta , Rajendran Praveen , Shobhit Singh
- 申请人： Anand C. Burman , Rama Mukherjee , Dhiraj Khattar , Sanjoy Mullick , Manu Jaggi , Manoj Kumar Singh , Mukesh Kumar , Deepak Prusthy , Pawan Kumar Gupta , Rajendran Praveen , Shobhit Singh
- 申请人地址： IN New Delhi
- 专利权人： Dabur Pharma Limited
- 当前专利权人： Dabur Pharma Limited
- 当前专利权人地址： IN New Delhi
- 优先权： IN1190/KOL/2005 20051228
- 国际申请： PCT/IN06/00504 WO 20061226
- 主分类号： C08G61/04
- IPC分类号： C08G61/04
摘要：
The invention relates to a biocompatible, non-biodegradable, and non-toxic polymer of formula (I), comprising of three monomeric units, selected from 1-Vinylpyrrolidone (VP), N-Isopropylacrylamide (NIPAM), and ester of Maleic anhydride and Polyethylene glycol (MPEG), cross-linked with a bi-functional vinyl derivative, of high purity and substantially free of respective toxic monomeric contaminants, and a process for preparation thereof. The invention further relates to nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds comprising the polymer of the invention, which are safe, less-toxic and convenient for bedside administration to patients in need thereof. Furthermore, the invention relates to a highly selective method for preparation of nanoparticulate pharmaceutical compositions of poorly water-soluble drugs or compounds.
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