公开(公告)号：US08853453B2

公开(公告)日：2014-10-07

申请号：US13574833

申请日：2011-01-31

Applicant: Hari Mohan Sriram ,  Mukesh Kumar Madhra ,  Mukesh Kumar Sharma

Inventor： Hari Mohan Sriram ,  Mukesh Kumar Madhra ,  Mukesh Kumar Sharma

IPC: C07C231/14 ,  C07C227/18 ,  C07C231/12 ,  C07C231/02 ,  C07C227/16

CPC classification number: C07C231/14 ,  C07C227/16 ,  C07C227/18 ,  C07C231/02 ,  C07C231/12 ,  C07C229/22 ,  C07C237/06 ,  C07C237/22

Abstract: The present invention relates to processes for reducing impurities in lacosamide during the preparation of lacosamide. The invention provides processes for minimizing or removing impurities such as (2R)-2-(acetylamino)-3-(benzylamino)-3-oxopropyl acetate of Formula II or (2R)-2-propanoylamino-N-benzyl-3-methoxypropionamide of Formula III in lacosamide.

Abstract translation: 本发明涉及在制备lacosamide期间减少lacosamide中的杂质的方法。 本发明提供了最小化或除去杂质的方法，例如式II的（2R）-2-（乙酰氨基）-3-（苄基氨基）-3-氧代丙酸乙酯或（2R）-2-丙酰基氨基-N-苄基-3-甲氧基丙酰胺 的拉莫糖胺。

公开(公告)号：US20130204042A1

公开(公告)日：2013-08-08

申请号：US13574833

申请日：2011-01-31

Applicant: Hari Mohan Sriram ,  Mukesh Kumar Madhra ,  Mukesh Kumar Sharma

Inventor： Hari Mohan Sriram ,  Mukesh Kumar Madhra ,  Mukesh Kumar Sharma

IPC: C07C231/14

CPC classification number: C07C231/14 ,  C07C227/16 ,  C07C227/18 ,  C07C231/02 ,  C07C231/12 ,  C07C229/22 ,  C07C237/06 ,  C07C237/22

Abstract: The present invention relates to processes for reducing impurities in lacosamide during the preparation of lacosamide. The invention provides processes for minimizing or removing impurities such as (2R)-2-(acetylamino)-3-(benzylamino)-3-oxopropyl acetate of Formula II or (2R)-2-propanoylamino-N-benzyl-3-methoxypropionamide of Formula III in lacosamide.

Abstract translation: 本发明涉及在制备lacosamide期间减少lacosamide中的杂质的方法。 本发明提供了最小化或除去杂质的方法，例如式II的（2R）-2-（乙酰氨基）-3-（苄基氨基）-3-氧代丙酸乙酯或（2R）-2-丙酰基氨基-N-苄基-3-甲氧基丙酰胺 的拉莫糖胺。

公开(公告)号：US20130085304A1

公开(公告)日：2013-04-04

申请号：US13510981

申请日：2010-11-19

Applicant: Mukesh Kumar Madhra ,  Hari Mohan Sriram ,  Mukesh Kumar Sharma ,  Satish Chandra Jha

Inventor： Mukesh Kumar Madhra ,  Hari Mohan Sriram ,  Mukesh Kumar Sharma ,  Satish Chandra Jha

IPC: C07C231/00

CPC classification number: C07C231/00 ,  C07C231/22 ,  C07C237/22

Abstract: The present invention relates to processes for the preparation of crystalline polymorphic forms of lacosamide (Formula I), including processes for inter-conversion among such polymorphic forms.

Abstract translation: 本发明涉及制备拉科酰胺结晶多晶型物（式I）的方法，包括这些多晶型物之间的相互转化方法。

公开(公告)号：US09153900B2

公开(公告)日：2015-10-06

申请号：US13274300

申请日：2011-10-14

Applicant: Mukesh Kumar

Inventor： Mukesh Kumar

IPC: A61N1/372 ,  H01R13/52 ,  A61N1/378 ,  H01R4/24 ,  A61B17/72 ,  A61B17/68

CPC classification number: H01R13/5219 ,  A61B17/7216 ,  A61B2017/681 ,  A61N1/3787 ,  H01R4/2445 ,  H01R13/5224 ,  H01R2201/12

Abstract: An implantable subcutaneous electrical socket and corresponding percutaneous plug are disclosed for controlling and/or energizing an implanted medical device, such as a bone distraction motor, within a patient. The subcutaneous electrical socket is accessed percutaneously by the plug, to connect data and power electrodes deployed from the plug into the socket to conduct control signals and electrical power from an external source to an implanted medical device within the patient. The socket and plug include insulating materials to prevent electrical shock to the patient.

公开(公告)号：US20150065704A1

公开(公告)日：2015-03-05

申请号：US14131823

申请日：2012-07-11

Applicant: Ketan Hirpara ,  Chandra Has Khanduri ,  Mukesh Kumar Sharma

Inventor： Ketan Hirpara ,  Chandra Has Khanduri ,  Mukesh Kumar Sharma

IPC: C07D223/28

CPC classification number: C07D223/28

Abstract: The present invention provides a novel process for the preparation of 10-oxo-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide, commonly known as oxcarbazepine, which is a medicament and a useful intermediate in the preparation of eslicarbazepine acetate. The present invention further provides a process for the preparation and purification of eslicarbazepine acetate.

Abstract translation: 本发明提供了一种制备10-氧代-10,11-二氢-5H-二苯并[b，f]吖庚因-5-甲酰胺（通常称为奥卡西平）的新方法，其为药物和有用的中间体 制备醋酸西拉西平。 本发明还提供了制备和纯化乙酸西酞西泮的方法。

公开(公告)号：US08935215B1

公开(公告)日：2015-01-13

申请号：US13097321

申请日：2011-04-29

Applicant: Mukesh Kumar Sharma

Inventor： Mukesh Kumar Sharma

IPC: G06F17/30

CPC classification number: G06F11/1464 ,  G06F11/1451 ,  G06F11/1469 ,  G06F17/30336

Abstract: Various systems and methods for restoring data using indexes. For example, one method involves receiving a request that includes a restore criterion. The method involves identifying a storage object in a backup storage device that meets the restore criterion, in response to the request. Detecting the identity of the storage object involves sending a query with the restore criterion to a client computing device that includes an index. The method also involves responding to the request with information identifying the storage object.

Abstract translation: 使用索引恢复数据的各种系统和方法。 例如，一种方法涉及接收包括恢复标准的请求。 该方法涉及根据该请求来识别满足恢复准则的备份存储设备中的存储对象。 检测存储对象的身份涉及将具有恢复标准的查询发送到包括索引的客户端计算设备。 该方法还涉及用识别存储对象的信息来响应该请求。

公开(公告)号：US20140181020A1

公开(公告)日：2014-06-26

申请号：US13724565

申请日：2012-12-21

Applicant: Olga Kreindlina ,  Oliver Berger ,  Santhosh N. ,  Karthik Narayanan Mohan ,  Walter Zimmermann ,  Torsten Buecheler ,  Sophie Kraut ,  Albert Neumueller ,  Steffen Witt ,  Dietmar Henkes ,  Guang Yang ,  Thomas Vogt ,  Matthias Becker ,  Martin Haerterich ,  Stefan Moeller ,  Kritesh Vasing ,  Knut Heusermann ,  Christian Hohmann ,  Marcus Echter ,  Xenia Rieger ,  Mohit V. Gadkari ,  Mukesh Kumar

Inventor： Olga Kreindlina ,  Oliver Berger ,  Santhosh N. ,  Karthik Narayanan Mohan ,  Walter Zimmermann ,  Torsten Buecheler ,  Sophie Kraut ,  Albert Neumueller ,  Steffen Witt ,  Dietmar Henkes ,  Guang Yang ,  Thomas Vogt ,  Matthias Becker ,  Martin Haerterich ,  Stefan Moeller ,  Kritesh Vasing ,  Knut Heusermann ,  Christian Hohmann ,  Marcus Echter ,  Xenia Rieger ,  Mohit V. Gadkari ,  Mukesh Kumar

IPC: G06F17/30

CPC classification number: G06F17/30575 ,  G06F17/30569

Abstract: According to one general aspect, a method may include replicating, to a software-as-a-service application, a plurality of pieces of master data from a physically remote master database. The method may also include converting the plurality of pieces of master data into one or more pieces of local data of the software-as-a-service application. The method may include changing one or more of either the pieces of master data or the pieces of local data. The method may further include synchronizing the changed pieces of either master data or local data between the remote master database and the software-as-a-service application.

Abstract translation: 根据一个一般方面，一种方法可以包括将来自物理上远程的主数据库的多条主数据复制到软件即服务应用程序。 该方法还可以包括将多条主数据转换为软件即服务应用的一个或多个本地数据。 该方法可以包括改变主数据或本地数据段中的一个或多个。 该方法还可以包括在远程主数据库和软件即服务应用之间同步主数据或本地数据的改变的部分。

公开(公告)号：US08663327B2

公开(公告)日：2014-03-04

申请号：US13366510

申请日：2012-02-06

Applicant: Mukesh Kumar ,  Robert M. Ronk ,  Daniel E. Williamson

Inventor： Mukesh Kumar ,  Robert M. Ronk ,  Daniel E. Williamson

IPC: A61F2/28

CPC classification number: A61F2/3609 ,  A61F2002/30332 ,  A61F2002/30589 ,  A61F2002/30682 ,  A61F2002/365

Abstract: A seal for preventing a bodily fluid from penetrating an orthopedic implant comprising a tapered section adapted to conformingly mate to a stem of a first implant component, and a collar section extending from and circumferentially surrounding a portion of the tapered section, the collar section adapted to mate to a base of a second implant component such that the tapered section and collar section define an opening therethrough configured to receive the first implant component.

Abstract translation: 一种用于防止体液穿透整形外科植入物的密封件，包括适于与第一植入部件的杆顺从地配合的锥形部分，以及从锥形部分的一部分延伸并周向围绕锥形部分的颈环部分， 配合到第二植入部件的基部，使得锥形部分和凸缘部分限定通过其构造成接收第一植入部件的开口。

公开(公告)号：US08586738B2

公开(公告)日：2013-11-19

申请号：US13390756

申请日：2010-08-12

Applicant: Mohammed Salman Hashmi ,  Mukesh Kumar Sharma ,  Chandra Has Khanduri

Inventor： Mohammed Salman Hashmi ,  Mukesh Kumar Sharma ,  Chandra Has Khanduri

IPC: C07D473/00

CPC classification number: C07D473/30

Abstract: The present invention provides a novel process for the preparation of pure valganciclovir hydrochloride.

Abstract translation: 本发明提供了一种制备纯缬更昔洛韦盐酸盐的新方法。

公开(公告)号：US08361380B2

公开(公告)日：2013-01-29

申请号：US13021987

申请日：2011-02-07

Applicant: Ned M. Hamman ,  James B. Fleming ,  Isaac Janson ,  Mukesh Kumar ,  Jason D. Meridew ,  Elizabeth A. Schlueter

Inventor： Ned M. Hamman ,  James B. Fleming ,  Isaac Janson ,  Mukesh Kumar ,  Jason D. Meridew ,  Elizabeth A. Schlueter

IPC: B22F3/11 ,  B22F3/16

CPC classification number: C09C1/00 ,  A61F2/30767 ,  A61F2/30907 ,  A61F2/34 ,  A61F2/38 ,  A61F2/3859 ,  A61F2/389 ,  A61F2002/30011 ,  A61F2002/30064 ,  A61F2002/30166 ,  A61F2002/30169 ,  A61F2002/302 ,  A61F2002/30205 ,  A61F2002/30224 ,  A61F2002/30235 ,  A61F2002/30261 ,  A61F2002/30383 ,  A61F2002/30451 ,  A61F2002/30454 ,  A61F2002/30604 ,  A61F2002/30736 ,  A61F2002/30827 ,  A61F2002/30878 ,  A61F2002/3092 ,  A61F2002/30968 ,  A61F2002/3411 ,  A61F2220/0025 ,  A61F2220/0058 ,  A61F2230/0028 ,  A61F2230/0047 ,  A61F2230/0065 ,  A61F2230/0067 ,  A61F2230/0069 ,  A61F2230/0082 ,  A61F2250/0023 ,  A61F2310/00017 ,  A61F2310/00023 ,  A61F2310/00029 ,  A61F2310/00059 ,  A61F2310/00131 ,  A61F2310/00592 ,  A61F2310/00958 ,  A61F2310/0097 ,  A61F2310/00976 ,  A61K35/12 ,  A61L27/04 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/25 ,  A61L2300/406 ,  A61L2300/414 ,  A61L2300/428 ,  A61L2300/606 ,  A61L2300/64 ,  B22F3/1125 ,  B22F2001/0066 ,  B22F2998/10 ,  C01P2004/61 ,  B22F1/0059 ,  B22F3/04 ,  B22F3/02 ,  B22F3/1021 ,  B22F3/1216

Abstract: A method for providing a porous metal implant. A mixture of biocompatible metal, a spacing agent, and a binder is provided. The mixture is formed into a shape and the spacing agent is removed to form a plurality of pores in the implant. A shaped porous metal is also provided.

Abstract translation: 一种用于提供多孔金属植入物的方法。 提供生物相容性金属，间隔剂和粘合剂的混合物。 将混合物形成为形状，并且移除间隔剂以在植入物中形成多个孔。 还提供了一种成形的多孔金属。